Effects of short-term treatment with the α1-blocker alfuzosin on urodynamic pressure/flow parameters in patients with benign prostatic hyperplasia

G. Martorana, C. Giberti, F. Di Silverio, M. Von Heland, P. Rigatti, R. Colombo, G. Casadei, P. Pacifico

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The objective of this double-blind, placebo-controlled urodynamic pressure/flow study was to assess the efficacy of short-term treatment with the α1-blocker alfuzosin in outflow obstruction of patients with symptomatic benign prostatic hyperplasia (BPH). Material and Methods: Urodynamic pressure/flow parameters were assessed after 2 weeks of placebo run-in, 4 weeks of placebo (47 patients) or 2.5 mg t.i.d. alfuzosin treatment (47 patients), followed by an 8-week extension period with alfuzosin (single-blind). Results and Conclusion: Four weeks of alfuzosin treatment significantly increased maximum flow (+29.0%) and decreased detrusor pressure at maximum flow (-30.2%), detrusor opening pressure (-39.4%) and maximum detrusor pressure (-28.7%). Short-term alfuzosin treatment improved outflow conditions in BPH by reducing prostatic urethral obstruction.

Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalEuropean Urology
Volume32
Issue number1
Publication statusPublished - 1997

Keywords

  • α-Antagonist
  • Alfuzosin
  • Benign prostatic hyperplasia
  • Urodynamics

ASJC Scopus subject areas

  • Urology

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