Abstract
Effects of a naturally occurring flavonoid, silybin, on histamine release from human basophils were examined, in order to assess the potential utility in the treatment of allergic disorders. The f-met peptide and anti-IgE-induced histamine release was significantly (P <0.05) inhibited in a concentration-dependent fashion. Conversely, no significant (P > 0.05) effect on calcium ionophore A23187-induced histamine secretion was documented. The inhibitory activity was significantly (P <0.05) reversed by elevating extracellular calcium concentrations. The anti-allergic properties of silybin can be reasonably ascribed to a membrane-stabilizing activity, possibly related to an interference in calcium influx. These results indicate that an in vivo evaluation of the anti-allergic activity of silybin would be worthwhile.
| Original language | English |
|---|---|
| Pages (from-to) | 747-752 |
| Number of pages | 6 |
| Journal | British Journal of Clinical Pharmacology |
| Volume | 24 |
| Issue number | 6 |
| Publication status | Published - 1987 |
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)