Effects of a naturally occurring flavonoid, silybin, on histamine release from human basophils were examined, in order to assess the potential utility in the treatment of allergic disorders. The f-met peptide and anti-IgE-induced histamine release was significantly (P <0.05) inhibited in a concentration-dependent fashion. Conversely, no significant (P > 0.05) effect on calcium ionophore A23187-induced histamine secretion was documented. The inhibitory activity was significantly (P <0.05) reversed by elevating extracellular calcium concentrations. The anti-allergic properties of silybin can be reasonably ascribed to a membrane-stabilizing activity, possibly related to an interference in calcium influx. These results indicate that an in vivo evaluation of the anti-allergic activity of silybin would be worthwhile.
|Number of pages||6|
|Journal||British Journal of Clinical Pharmacology|
|Publication status||Published - 1987|
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)