Effects of silybin on histamine release from human basophil leucocytes

A. Miadonna, A. Tedeschi, E. Leggieri, M. Lorini, M. Froldi, C. Zanussi

Research output: Contribution to journalArticlepeer-review

Abstract

Effects of a naturally occurring flavonoid, silybin, on histamine release from human basophils were examined, in order to assess the potential utility in the treatment of allergic disorders. The f-met peptide and anti-IgE-induced histamine release was significantly (P <0.05) inhibited in a concentration-dependent fashion. Conversely, no significant (P > 0.05) effect on calcium ionophore A23187-induced histamine secretion was documented. The inhibitory activity was significantly (P <0.05) reversed by elevating extracellular calcium concentrations. The anti-allergic properties of silybin can be reasonably ascribed to a membrane-stabilizing activity, possibly related to an interference in calcium influx. These results indicate that an in vivo evaluation of the anti-allergic activity of silybin would be worthwhile.

Original languageEnglish
Pages (from-to)747-752
Number of pages6
JournalBritish Journal of Clinical Pharmacology
Volume24
Issue number6
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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