Effects of single and repeated doses of the calcium antagonist felodipine on blood pressure, renal function, electrolytes and water balance, and renin-angiotensin-aldosterone system in hypertensive patients

G. Leonetti, R. Gradnik, L. Terzoli, M. Fruscio, L. Rupoli, C. Cuspidi, L. Sampieri, A. Zanchetti

Research output: Contribution to journalArticle

Abstract

Doses of 10 mg b.i.d. of the new dihydropyridine calcium antagonist, felodipine, were tested for seven consecutive days in 11 hospitalized hypertensive patients. A significant reduction of both systolic and diastolic blood pressures, with patients in both the supine and upright positions, occurred immediately after the first dose and was maintained (daily average 15%) throughout the following days. An increase in heart rate was observed after the first dose (15 and 23 beats/min, in supine and upright postures), and subsequently declined to average values of 8 and 14 beats/min on the seventh day. There was a marked natriuretic response during the first and second day, during which an average negative sodium balance of 95 mmol developed; on the following days sodium output was not significantly different from control, but a negative balance averaging 135 mmol was still present on the seventh day of felodipine administration. A moderate negative potassium balance also progressively developed and reached -48 mmol on the seventh day. Glomerular filtration rate was unchanged, but renal plasma flow increased significantly during administration of felodipine. Plasma renin activity and plasma aldosterone were also increased very moderately by felodipine. Compared with previous observations by our group with higher doses of felodipine (12.5, 25, and 50 mg t.i.d.), 10 mg b.i.d. of this new calcium antagonist appear to exert a marked and prolonged blood pressure reduction, accompanied by a definite natriuretic instead of an antinatriuretic effect.

Original languageEnglish
Pages (from-to)1243-1248
Number of pages6
JournalJournal of Cardiovascular Pharmacology
Volume8
Issue number6
Publication statusPublished - 1986

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Felodipine
Water-Electrolyte Balance
Renin-Angiotensin System
Blood Pressure
Calcium
Kidney
Sodium
Renal Plasma Flow
Supine Position
Aldosterone
Posture
Glomerular Filtration Rate
Renin
Potassium
Heart Rate

Keywords

  • Calcium antagonist
  • Felodipine
  • Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Effects of single and repeated doses of the calcium antagonist felodipine on blood pressure, renal function, electrolytes and water balance, and renin-angiotensin-aldosterone system in hypertensive patients. / Leonetti, G.; Gradnik, R.; Terzoli, L.; Fruscio, M.; Rupoli, L.; Cuspidi, C.; Sampieri, L.; Zanchetti, A.

In: Journal of Cardiovascular Pharmacology, Vol. 8, No. 6, 1986, p. 1243-1248.

Research output: Contribution to journalArticle

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