Effects of sinoaortic denervation on blood pressure, pulse interval, sympathetic nerve activity and diaphragmatic electromyogram variability in conscious rats

M. R. Ushizima, E. D. Moreira, E. T. Costa, P. Castiglioni, E. M. Krieger, M. Di Rienzo, I. A. Cestari

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The effects of sinoaortic denervation on systolic and diastolic blood pressure (SBP, DBP), pulse interval (PI), renal sympathetic nerve activity (RSNA) and respiratory activity (RA) were investigated in conscious Wistar rats by wide-band spectral and coherence analysis. Signals were recorded during 90 minutes 6 hour after sinoaortic denervation (SAD, n=8) and in sham operated rats (n=8). After SAD animals showed higher BP mean and variability, heart rate and RSNA and lower PI variability and respiratory frequency. The rhythmic component centered at 0.4 Hz seen in RSNA in sham rats was blunted after SAD. The results suggest that PI variability and the RSNA component at 0.4 Hz depend on baroreceptors and may contribute to regulate BP within a physiological range of variability.

Original languageEnglish
Title of host publicationComputers in Cardiology
Pages485-488
Number of pages4
Publication statusPublished - 2001
EventComputer in Cardiology 2001 - Rotterdam, Netherlands
Duration: Sep 23 2001 → Sep 26 2001

Other

OtherComputer in Cardiology 2001
CountryNetherlands
CityRotterdam
Period9/23/01 → 9/26/01

ASJC Scopus subject areas

  • Software
  • Cardiology and Cardiovascular Medicine

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    Ushizima, M. R., Moreira, E. D., Costa, E. T., Castiglioni, P., Krieger, E. M., Di Rienzo, M., & Cestari, I. A. (2001). Effects of sinoaortic denervation on blood pressure, pulse interval, sympathetic nerve activity and diaphragmatic electromyogram variability in conscious rats. In Computers in Cardiology (pp. 485-488)