Effects of slow repetitive transcranial magnetic stimulation in patients with corticobasal syndrome

Carlo Civardi, Fabrizio Pisano, Carmen Delconte, Alessandra Collini, Francesco Monaco

Research output: Contribution to journalArticlepeer-review

Abstract

Corticobasal syndrome is characterized by asymmetric cortical sensorimotor dysfunction and parkinsonism; an altered cortical excitability has been reported. We explored with transcranial magnetic stimulation the motor cortical excitability in corticobasal syndrome, and the effects of slow repetitive transcranial magnetic stimulation. With transcranial magnetic stimulation, we studied two corticobasal syndrome patients. We determined bilaterally from the first dorsal interosseous muscle: relaxed threshold, and contralateral and ipsilateral silent period. We also evaluated the contralateral silent period after active/sham slow repetitive transcranial magnetic stimulation on the most affected side. At T0 the silent period was bilaterally short. On the most affected side, active slow repetitive transcranial magnetic stimulation induced a short lasting prolongation of the contralateral silent period. In corticobasal syndrome, transcranial magnetic stimulation showed a reduction cortical inhibitory phenomenon potentially reversed transiently by slow repetitive transcranial magnetic stimulation.

Original languageEnglish
Pages (from-to)1007-1009
Number of pages3
JournalNeurological Sciences
Volume36
Issue number6
DOIs
Publication statusPublished - Feb 19 2015

Keywords

  • Cortical excitability
  • Corticobasal syndrome
  • Slow repetitive transcranial magnetic stimulation
  • Transcranial magnetic stimulation
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

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