Effects of smoking cessation on the risk of laryngeal cancer: An overview of published studies

Cristina Bosetti, Werner Garavello, Silvano Gallus, Carlo L. Vecchia

Research output: Contribution to journalArticlepeer-review


Epidemiological studies showed that stopping smoking substantially decreases the risk of lung cancer. With reference to laryngeal cancer, at least four cohort studies and 15 case-control studies reported information on smoking cessation. These studies indicated that the risk of laryngeal cancer is considerably reduced in ex-smokers as compared to current smokers. The relative risk steeply decreases with time since stopping smoking, with reductions by about 60% after 10-15 years since cessation, and even larger after 20 years. The favorable effect of stopping smoking is already evident within few years after cessation, thus suggesting that smoking has a relevant impact on the late stage of laryngeal carcinogenesis. However, several years after stopping smoking, ex-smokers still have elevated risks of laryngeal cancer as compared to never smokers. In conclusion, the epidemiological evidence clearly indicates that cessation of smoking is the best measure to reduce laryngeal cancer risk, the beneficial effect being evident within a few years after cessation, and steadily increasing with passing time since cessation.

Original languageEnglish
Pages (from-to)866-872
Number of pages7
JournalOral Oncology
Issue number9
Publication statusPublished - Oct 2006


  • Laryngeal cancer
  • Review
  • Risk factors
  • Smoking cessation

ASJC Scopus subject areas

  • Oncology


Dive into the research topics of 'Effects of smoking cessation on the risk of laryngeal cancer: An overview of published studies'. Together they form a unique fingerprint.

Cite this