Effects of somatostatin infusion in four patients with malignant carcinoid syndrome

M. Quatrini, G. Basilisco, D. Conte, A. Bozzani, M. T. Bardella, P. A. Bianchi

Research output: Contribution to journalArticle

Abstract

Somatostatin (4 μg/min, cyclic form) was infused for 24 h on six occasions in four patients with carcinoid ileal tumor and multiple liver metastases. During infusion, spontaneous flushes and/or diarrhea were markedly reduced with a return to the pretreatment pattern on the next day. Urinary 5-hydroxyindole acetic acid excretion and plasma gastrin were not significantly changed, whereas plasma insulin presented the expected decrease and rebound. These results confirm that carcinoid symptoms are somatostatin-sensitive but do not provide evidence that serotonin or gastrin play a major role in inducing these symptoms.

Original languageEnglish
Pages (from-to)149-151
Number of pages3
JournalAmerican Journal of Gastroenterology
Volume78
Issue number3
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Gastroenterology

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    Quatrini, M., Basilisco, G., Conte, D., Bozzani, A., Bardella, M. T., & Bianchi, P. A. (1983). Effects of somatostatin infusion in four patients with malignant carcinoid syndrome. American Journal of Gastroenterology, 78(3), 149-151.