Effects of some typical and atypical antidepressants on GAD activity in various brain regions

L. Rampello, F. Patti, F. Condorelli, A. Reggio, A. Prato, P. L. Canonico, F. Nicoletti

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The authors have investigated the effects of acute or chronic injection of typical and atypical antidepressants on the activity of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) in discrete brain regions. Very significant changes in GAD activity were observed only with sulpiride and nomifensine, two atypical antidepressants that selectively influence dopaminergic transmission and, in turn, prolactin secretion.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalEncephale
Volume8
Issue number1
Publication statusPublished - 1982

Fingerprint

Second-Generation Antidepressive Agents
Nomifensine
Sulpiride
Glutamate Decarboxylase
Brain
Prolactin
gamma-Aminobutyric Acid
Injections
Enzymes
Antidepressants

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Rampello, L., Patti, F., Condorelli, F., Reggio, A., Prato, A., Canonico, P. L., & Nicoletti, F. (1982). Effects of some typical and atypical antidepressants on GAD activity in various brain regions. Encephale, 8(1), 89-94.

Effects of some typical and atypical antidepressants on GAD activity in various brain regions. / Rampello, L.; Patti, F.; Condorelli, F.; Reggio, A.; Prato, A.; Canonico, P. L.; Nicoletti, F.

In: Encephale, Vol. 8, No. 1, 1982, p. 89-94.

Research output: Contribution to journalArticle

Rampello, L, Patti, F, Condorelli, F, Reggio, A, Prato, A, Canonico, PL & Nicoletti, F 1982, 'Effects of some typical and atypical antidepressants on GAD activity in various brain regions', Encephale, vol. 8, no. 1, pp. 89-94.
Rampello L, Patti F, Condorelli F, Reggio A, Prato A, Canonico PL et al. Effects of some typical and atypical antidepressants on GAD activity in various brain regions. Encephale. 1982;8(1):89-94.
Rampello, L. ; Patti, F. ; Condorelli, F. ; Reggio, A. ; Prato, A. ; Canonico, P. L. ; Nicoletti, F. / Effects of some typical and atypical antidepressants on GAD activity in various brain regions. In: Encephale. 1982 ; Vol. 8, No. 1. pp. 89-94.
@article{952f2d1a25a4480c9f779d8bdaeb46cc,
title = "Effects of some typical and atypical antidepressants on GAD activity in various brain regions",
abstract = "The authors have investigated the effects of acute or chronic injection of typical and atypical antidepressants on the activity of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) in discrete brain regions. Very significant changes in GAD activity were observed only with sulpiride and nomifensine, two atypical antidepressants that selectively influence dopaminergic transmission and, in turn, prolactin secretion.",
author = "L. Rampello and F. Patti and F. Condorelli and A. Reggio and A. Prato and Canonico, {P. L.} and F. Nicoletti",
year = "1982",
language = "English",
volume = "8",
pages = "89--94",
journal = "L'Encephale",
issn = "0013-7006",
publisher = "Elsevier Masson",
number = "1",

}

TY - JOUR

T1 - Effects of some typical and atypical antidepressants on GAD activity in various brain regions

AU - Rampello, L.

AU - Patti, F.

AU - Condorelli, F.

AU - Reggio, A.

AU - Prato, A.

AU - Canonico, P. L.

AU - Nicoletti, F.

PY - 1982

Y1 - 1982

N2 - The authors have investigated the effects of acute or chronic injection of typical and atypical antidepressants on the activity of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) in discrete brain regions. Very significant changes in GAD activity were observed only with sulpiride and nomifensine, two atypical antidepressants that selectively influence dopaminergic transmission and, in turn, prolactin secretion.

AB - The authors have investigated the effects of acute or chronic injection of typical and atypical antidepressants on the activity of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) in discrete brain regions. Very significant changes in GAD activity were observed only with sulpiride and nomifensine, two atypical antidepressants that selectively influence dopaminergic transmission and, in turn, prolactin secretion.

UR - http://www.scopus.com/inward/record.url?scp=0020070620&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020070620&partnerID=8YFLogxK

M3 - Article

VL - 8

SP - 89

EP - 94

JO - L'Encephale

JF - L'Encephale

SN - 0013-7006

IS - 1

ER -