Effects of some typical and atypical antidepressants on GAD activity in various brain regions

L. Rampello, F. Patti, F. Condorelli, A. Reggio, A. Prato, P. L. Canonico, F. Nicoletti

Research output: Contribution to journalArticle

Abstract

The authors have investigated the effects of acute or chronic injection of typical and atypical antidepressants on the activity of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) in discrete brain regions. Very significant changes in GAD activity were observed only with sulpiride and nomifensine, two atypical antidepressants that selectively influence dopaminergic transmission and, in turn, prolactin secretion.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalEncephale
Volume8
Issue number1
Publication statusPublished - 1982

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ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Rampello, L., Patti, F., Condorelli, F., Reggio, A., Prato, A., Canonico, P. L., & Nicoletti, F. (1982). Effects of some typical and atypical antidepressants on GAD activity in various brain regions. Encephale, 8(1), 89-94.