Abstract
In eleven patients with stage II-III pulmonary sarcoidosis as assessed by mediastinoscopy or open lung biopsy, we carried out a functional study by evaluating static and dynamic pulmonary volumes, diffusing lung properties (TL(CO)), K(CO)), and mechanical properties: resistance of the airway, flow-volume curve, pressure-volume curve, flow-pressure curve, and dynamic compliance. In 7 of 11 patients a clinical and functional follow up during steroid treatment over a period of 5 months to 3 years was also performed. Before treatment diffusing properties were in the normal range in 6 of 11 subjects, reduced in 4, and increased in 1. Elastic properties studied in 8 patients were in the normal range, whereas peripheral airway involvement was noted in 4 nonsmokers. During the follow-up the changes noted in diffusing lung properties on the whole paralleled the clinical and radiologic improvement or relapses after cessation of therapy. In contrast, no changes in elastic properties or lung volume were noted. We concluded that steroid treatment seems to improve parenchyma lung involvement in most cases as shown by the increase in diffusing lung properties.
| Original language | English |
|---|---|
| Pages (from-to) | 468-475 |
| Number of pages | 8 |
| Journal | International Journal of Clinical Pharmacology Therapy and Toxicology |
| Volume | 21 |
| Issue number | 9 |
| Publication status | Published - 1983 |
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ASJC Scopus subject areas
- Toxicology
- Pharmacology (medical)
Cite this
Effects of steroid therapy on pulmonary involvement in sarcoidosis. / Scano, G.; Monechi, G. C.; Gigliotti, F.; Stendardi, L.; Esposito-Iacenna, V.; Tarducci, G.; Schiffini, P.
In: International Journal of Clinical Pharmacology Therapy and Toxicology, Vol. 21, No. 9, 1983, p. 468-475.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of steroid therapy on pulmonary involvement in sarcoidosis
AU - Scano, G.
AU - Monechi, G. C.
AU - Gigliotti, F.
AU - Stendardi, L.
AU - Esposito-Iacenna, V.
AU - Tarducci, G.
AU - Schiffini, P.
PY - 1983
Y1 - 1983
N2 - In eleven patients with stage II-III pulmonary sarcoidosis as assessed by mediastinoscopy or open lung biopsy, we carried out a functional study by evaluating static and dynamic pulmonary volumes, diffusing lung properties (TL(CO)), K(CO)), and mechanical properties: resistance of the airway, flow-volume curve, pressure-volume curve, flow-pressure curve, and dynamic compliance. In 7 of 11 patients a clinical and functional follow up during steroid treatment over a period of 5 months to 3 years was also performed. Before treatment diffusing properties were in the normal range in 6 of 11 subjects, reduced in 4, and increased in 1. Elastic properties studied in 8 patients were in the normal range, whereas peripheral airway involvement was noted in 4 nonsmokers. During the follow-up the changes noted in diffusing lung properties on the whole paralleled the clinical and radiologic improvement or relapses after cessation of therapy. In contrast, no changes in elastic properties or lung volume were noted. We concluded that steroid treatment seems to improve parenchyma lung involvement in most cases as shown by the increase in diffusing lung properties.
AB - In eleven patients with stage II-III pulmonary sarcoidosis as assessed by mediastinoscopy or open lung biopsy, we carried out a functional study by evaluating static and dynamic pulmonary volumes, diffusing lung properties (TL(CO)), K(CO)), and mechanical properties: resistance of the airway, flow-volume curve, pressure-volume curve, flow-pressure curve, and dynamic compliance. In 7 of 11 patients a clinical and functional follow up during steroid treatment over a period of 5 months to 3 years was also performed. Before treatment diffusing properties were in the normal range in 6 of 11 subjects, reduced in 4, and increased in 1. Elastic properties studied in 8 patients were in the normal range, whereas peripheral airway involvement was noted in 4 nonsmokers. During the follow-up the changes noted in diffusing lung properties on the whole paralleled the clinical and radiologic improvement or relapses after cessation of therapy. In contrast, no changes in elastic properties or lung volume were noted. We concluded that steroid treatment seems to improve parenchyma lung involvement in most cases as shown by the increase in diffusing lung properties.
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M3 - Article
C2 - 6629552
AN - SCOPUS:0020521892
VL - 21
SP - 468
EP - 475
JO - International Journal of Clinical Pharmacology and Therapeutics
JF - International Journal of Clinical Pharmacology and Therapeutics
SN - 0174-4879
IS - 9
ER -