Effects of subchronic minaprine on dopamine release in the ventral striatum and on immobility in the forced swimming test

Assunta Imperato; Maria Carmen Obinu; Simona Cabib; Vincenzo Cestari; Stefano Puglisi-Allegra

doi:10.1016/0304-3940(94)90842-7

Effects of subchronic minaprine on dopamine release in the ventral striatum and on immobility in the forced swimming test

Assunta Imperato, Maria Carmen Obinu, Simona Cabib, Vincenzo Cestari, Stefano Puglisi-Allegra

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Subchronic (5 mg/kg daily for 9 consecutive days) but not acute minaprine treatment enhanced in vivo dopamine release in the limbic part of the striatum of rats as revealed by intracerebral microdialysis. Moreover, the same subchronic treatment with minaprine reduced immobility in the forced swimming test. The anti-immobility effect of minaprine was not evident after a single injection of the antidepressant. Finally, the subchronic treatment with minaprine was devoid of effects in an activity test. These results suggest that enhanced dopaminergic transmission may contribute to the pharmacological and clinical profile of this drug.

Original language	English
Pages (from-to)	69-72
Number of pages	4
Journal	Neuroscience Letters
Volume	166
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(94)90842-7
Publication status	Published - Jan 17 1994

Keywords

Activity
Antidepressant
Dialysis
Porsolt's test
Rat

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(94)90842-7

Cite this

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title = "Effects of subchronic minaprine on dopamine release in the ventral striatum and on immobility in the forced swimming test",

abstract = "Subchronic (5 mg/kg daily for 9 consecutive days) but not acute minaprine treatment enhanced in vivo dopamine release in the limbic part of the striatum of rats as revealed by intracerebral microdialysis. Moreover, the same subchronic treatment with minaprine reduced immobility in the forced swimming test. The anti-immobility effect of minaprine was not evident after a single injection of the antidepressant. Finally, the subchronic treatment with minaprine was devoid of effects in an activity test. These results suggest that enhanced dopaminergic transmission may contribute to the pharmacological and clinical profile of this drug.",

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AU - Imperato, Assunta

AU - Obinu, Maria Carmen

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AU - Cestari, Vincenzo

AU - Puglisi-Allegra, Stefano

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AB - Subchronic (5 mg/kg daily for 9 consecutive days) but not acute minaprine treatment enhanced in vivo dopamine release in the limbic part of the striatum of rats as revealed by intracerebral microdialysis. Moreover, the same subchronic treatment with minaprine reduced immobility in the forced swimming test. The anti-immobility effect of minaprine was not evident after a single injection of the antidepressant. Finally, the subchronic treatment with minaprine was devoid of effects in an activity test. These results suggest that enhanced dopaminergic transmission may contribute to the pharmacological and clinical profile of this drug.

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Effects of subchronic minaprine on dopamine release in the ventral striatum and on immobility in the forced swimming test

Abstract

Keywords

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