Effects of surgery on peripheral N-terminal propeptide of type III procollagen in patients with Crohn's disease

Matilde De Simone, Michele M. Ciulla, Ugo Cioffi, Luca Poggi, Barbara Oreggia, Roberta Paliotti, Fiorenzo Botti, Alberto Carrara, Fiorenza Agosti, Alessandro Sartorio, Ettore Contessini-Avesani

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This study investigates the effects of surgery on collagen turnover in patients affected by Crohn's disease (CD). Fifteen patients affected by active CD, assessed according to the Crohn's disease activity index, and confirmed by histology, with different pharmacological treatments, were enrolled in the study. N-Terminal propeptide of type III collagen was assessed on peripheral blood before and 6 months after surgery, as an index of collagen turnover. A control group of 15 healthy age- and sex-matched subjects was also studied. In CD patients peripheral N-terminal propeptide of type III collagen serum levels were significantly higher than in controls before surgery (5. 0∈±∈1.8 vs 2.7∈±∈0.7 μg/l, respectively; p∈=∈0.0001). Six months after these values were significantly reduced (from 5.0∈±∈1.8 to 3.1∈±∈0.8 μg/l; p∈=∈0.003). Independently on the pretreatment regimen and the duration of the disease, an improvement in the patients' symptoms was observed. The surgical resection of the affected intestinal segment in CD patients seems to be able to break down the collagen synthesis processes. Peripheral N-terminal propeptide of type III collagen could be seen as an additive marker to clinical and endoscopic observations after surgery.

Original languageEnglish
Pages (from-to)1361-1364
Number of pages4
JournalJournal of Gastrointestinal Surgery
Issue number10
Publication statusPublished - Oct 2007



  • Crohn's disease
  • Inflammatory bowel disease
  • Procollagen type III peptide

ASJC Scopus subject areas

  • Surgery

Cite this

De Simone, M., Ciulla, M. M., Cioffi, U., Poggi, L., Oreggia, B., Paliotti, R., Botti, F., Carrara, A., Agosti, F., Sartorio, A., & Contessini-Avesani, E. (2007). Effects of surgery on peripheral N-terminal propeptide of type III procollagen in patients with Crohn's disease. Journal of Gastrointestinal Surgery, 11(10), 1361-1364. https://doi.org/10.1007/s11605-007-0233-9