Effects of surgical and adjuvant therapies for breast cancer on sexuality, cognitive functions, and body weight

Nicoletta Biglia, Giulia Moggio, Elisa Peano, Paola Sgandurra, Riccardo Ponzone, Rossella E. Nappi, Piero Sismondi

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Introduction. Breast cancer and its treatment negatively affect the important aspects of a woman's life such as sexual health, cognitive functions, body image, and weight. Abrupt estrogen deficiency following chemotherapy and/or hormonal therapy plays an important role in worsening of sexuality. Aim.: To evaluate the impact of breast cancer treatment on sexual functioning, cognitive function, and body weight in premenopausal women. Methods.: Thirty-five women with a premenopausal diagnosis of breast cancer who are candidate to adjuvant treatment completed validated questionnaires on menopausal symptoms, sexuality, partner relationship, depression, body image, and cognitive functions after surgery (T0), then after chemotherapy or at least 6 months of endocrine therapy (T1), and after 1 year (T2). In addition, gynecological and dietological examinations were performed. Main Outcome Measure.: The following validated questionnaires were used: Greene Climacteric Scale, Beck Depression Inventory, Body Attitude Test, McCoy revised Italian version McCoy Female Sexuality Questionnaire, Cues for Sexual Desire Scale, Dyadic Adjustment Scale, Numeric Matrix Test and Rey uditory-verbal learning test, to measure cognitive functions, a recall 24 H questionnaire to evaluate food intake, Minnesota Leisure Time Physical Activity questionnaire and Eating Attitude Test-40, while anthropometric and plicometry data were assessed by a dietitian. Results.: Low levels of sexual functioning were registered at baseline; a further decrease in sexual activity, quality of the partnered relationship, desire, and arousability was demonstrated at T1 and T2. We found a significant increase in hot flushes and anxiety. Nonsignificant deterioration of body image was demonstrated. Although women reported losing memory and concentration, " chemobrain" effect was not demonstrated as cognitive tests improved after 6 months, probably because of " learning effect." Women who had undergone chemotherapy gained weight and fat disposition was typically android. Conclusions.: Young women undergoing adjuvant breast cancer therapy experience a heavy impairment in important quality of life domains as sexuality and targeted support interventions are needed.

Original languageEnglish
Pages (from-to)1891-1900
Number of pages10
JournalJournal of Sexual Medicine
Volume7
Issue number5
DOIs
Publication statusPublished - 2010

Fingerprint

Sexuality
Cognition
Body Weight
Breast Neoplasms
Body Image
Drug Therapy
Therapeutics
Eating
Play Therapy
Depression
Social Adjustment
Weights and Measures
Verbal Learning
Nutritionists
Leisure Activities
Reproductive Health
Sexual Behavior
Cues
Estrogens
Anxiety

Keywords

  • Adjuvant Therapy
  • Body Weight
  • Breast Cancer Treatment Associated Sexual Function
  • Cognitive Functions

ASJC Scopus subject areas

  • Urology
  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Medicine(all)

Cite this

Effects of surgical and adjuvant therapies for breast cancer on sexuality, cognitive functions, and body weight. / Biglia, Nicoletta; Moggio, Giulia; Peano, Elisa; Sgandurra, Paola; Ponzone, Riccardo; Nappi, Rossella E.; Sismondi, Piero.

In: Journal of Sexual Medicine, Vol. 7, No. 5, 2010, p. 1891-1900.

Research output: Contribution to journalArticle

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AU - Ponzone, Riccardo

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AU - Sismondi, Piero

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N2 - Introduction. Breast cancer and its treatment negatively affect the important aspects of a woman's life such as sexual health, cognitive functions, body image, and weight. Abrupt estrogen deficiency following chemotherapy and/or hormonal therapy plays an important role in worsening of sexuality. Aim.: To evaluate the impact of breast cancer treatment on sexual functioning, cognitive function, and body weight in premenopausal women. Methods.: Thirty-five women with a premenopausal diagnosis of breast cancer who are candidate to adjuvant treatment completed validated questionnaires on menopausal symptoms, sexuality, partner relationship, depression, body image, and cognitive functions after surgery (T0), then after chemotherapy or at least 6 months of endocrine therapy (T1), and after 1 year (T2). In addition, gynecological and dietological examinations were performed. Main Outcome Measure.: The following validated questionnaires were used: Greene Climacteric Scale, Beck Depression Inventory, Body Attitude Test, McCoy revised Italian version McCoy Female Sexuality Questionnaire, Cues for Sexual Desire Scale, Dyadic Adjustment Scale, Numeric Matrix Test and Rey uditory-verbal learning test, to measure cognitive functions, a recall 24 H questionnaire to evaluate food intake, Minnesota Leisure Time Physical Activity questionnaire and Eating Attitude Test-40, while anthropometric and plicometry data were assessed by a dietitian. Results.: Low levels of sexual functioning were registered at baseline; a further decrease in sexual activity, quality of the partnered relationship, desire, and arousability was demonstrated at T1 and T2. We found a significant increase in hot flushes and anxiety. Nonsignificant deterioration of body image was demonstrated. Although women reported losing memory and concentration, " chemobrain" effect was not demonstrated as cognitive tests improved after 6 months, probably because of " learning effect." Women who had undergone chemotherapy gained weight and fat disposition was typically android. Conclusions.: Young women undergoing adjuvant breast cancer therapy experience a heavy impairment in important quality of life domains as sexuality and targeted support interventions are needed.

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