Effects of surgical menopause and estrogen replacement therapy on atrio-ventricular conduction and ventricular repolarization

Mario Siniscalchi, Pasquale De Franciscis, Stefano Palomba, Carmen Di Palo, Nicola Colacurci, Carmine Nappi, Dario Giugliano

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the effect of surgical menopause and estrogen replacement therapy on atrio-ventricular conduction and ventricular repolarization in women. Methods: In a prospective, randomized, double-blind, placebo-controlled clinical trial 50 women underwent hystero-salpingo-oophorectomy. Twenty-five women were treated with 50 μg/die of transdermal estradiol and the other 25 were treated with placebo patches. The duration of the treatment was 12 cycles. Before surgery and after 12 cycles of treatment, a standard electrocardiogram was performed to evaluate atrio-ventricular conduction time and cardiac repolarization time. Results: No significant variations in atrio-ventricuar conduction time and cardiac repolarization time were detected between the two groups at entry, nor was there any difference in both groups after 12 cycles of treatment with transdermal estradiol. Conclusions: Surgical menopause and estrogen replacement therapy do not modify atrio-ventricular conduction and ventricular repolarization in women.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalMaturitas
Volume40
Issue number1
DOIs
Publication statusPublished - Oct 31 2001

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Keywords

  • CVD
  • ECG
  • Estrogen replacement therapy
  • Postmenopause
  • Sex hormones

ASJC Scopus subject areas

  • Ageing
  • Obstetrics and Gynaecology

Cite this

Siniscalchi, M., De Franciscis, P., Palomba, S., Di Palo, C., Colacurci, N., Nappi, C., & Giugliano, D. (2001). Effects of surgical menopause and estrogen replacement therapy on atrio-ventricular conduction and ventricular repolarization. Maturitas, 40(1), 47-51. https://doi.org/10.1016/S0378-5122(01)00231-6