Abstract
Background: Topical application of inhibitors of HMGCoA reductase, the rate-limiting enzyme of cholesterol synthesis, has been shown to induce impairment of barrier function. Objective: Assessing whether oral administration of statins used for reducing blood levels of cholesterol induces functional changes in stratum corneum barrier. Materials and Methods: 69 subjects of both sexes undergoing treatment for hypercholesterolemia (mean age 48 ± 11 years) entered the study; 43 had been treated with simvastatin and 11 with pravastatin for 6 months; 15 only on dietary regimen served as controls. Efficiency of stratum corneum water barrier was evaluated by transepidermal water loss (TEWL) measurement using an evaporimeter; water-holding capacity of the stratum corneum was assessed by the sorption-desorption test measured by capacitance. Statistical analysis was performed using ANOVA. Results: No differences were found between the groups (simvastatin, pravastatin, diet) concerning both basal TEWL and the dynamic of water binding in the stratum corneum. Conclusions: Prolonged treatment with cholesterol-lowering drugs based on inhibition of HMGCoA reductase does not alter the permeability barrier of the skin.
| Original language | English |
|---|---|
| Pages (from-to) | 214-216 |
| Number of pages | 3 |
| Journal | Dermatology |
| Volume | 192 |
| Issue number | 3 |
| Publication status | Published - 1996 |
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Keywords
- Cholesterol synthesis
- HMG-CoA reductase
- Skin barrier function
- Statins
- Transepidermal water loss
- Water-holding capacity
ASJC Scopus subject areas
- Dermatology
Cite this
Effects of systemic treatment with statins on skin barrier function and stratum corneum water-holding capacity. / Brazzelli, V.; Distante, F.; Perani, G.; Berardesca, E.
In: Dermatology, Vol. 192, No. 3, 1996, p. 214-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of systemic treatment with statins on skin barrier function and stratum corneum water-holding capacity
AU - Brazzelli, V.
AU - Distante, F.
AU - Perani, G.
AU - Berardesca, E.
PY - 1996
Y1 - 1996
N2 - Background: Topical application of inhibitors of HMGCoA reductase, the rate-limiting enzyme of cholesterol synthesis, has been shown to induce impairment of barrier function. Objective: Assessing whether oral administration of statins used for reducing blood levels of cholesterol induces functional changes in stratum corneum barrier. Materials and Methods: 69 subjects of both sexes undergoing treatment for hypercholesterolemia (mean age 48 ± 11 years) entered the study; 43 had been treated with simvastatin and 11 with pravastatin for 6 months; 15 only on dietary regimen served as controls. Efficiency of stratum corneum water barrier was evaluated by transepidermal water loss (TEWL) measurement using an evaporimeter; water-holding capacity of the stratum corneum was assessed by the sorption-desorption test measured by capacitance. Statistical analysis was performed using ANOVA. Results: No differences were found between the groups (simvastatin, pravastatin, diet) concerning both basal TEWL and the dynamic of water binding in the stratum corneum. Conclusions: Prolonged treatment with cholesterol-lowering drugs based on inhibition of HMGCoA reductase does not alter the permeability barrier of the skin.
AB - Background: Topical application of inhibitors of HMGCoA reductase, the rate-limiting enzyme of cholesterol synthesis, has been shown to induce impairment of barrier function. Objective: Assessing whether oral administration of statins used for reducing blood levels of cholesterol induces functional changes in stratum corneum barrier. Materials and Methods: 69 subjects of both sexes undergoing treatment for hypercholesterolemia (mean age 48 ± 11 years) entered the study; 43 had been treated with simvastatin and 11 with pravastatin for 6 months; 15 only on dietary regimen served as controls. Efficiency of stratum corneum water barrier was evaluated by transepidermal water loss (TEWL) measurement using an evaporimeter; water-holding capacity of the stratum corneum was assessed by the sorption-desorption test measured by capacitance. Statistical analysis was performed using ANOVA. Results: No differences were found between the groups (simvastatin, pravastatin, diet) concerning both basal TEWL and the dynamic of water binding in the stratum corneum. Conclusions: Prolonged treatment with cholesterol-lowering drugs based on inhibition of HMGCoA reductase does not alter the permeability barrier of the skin.
KW - Cholesterol synthesis
KW - HMG-CoA reductase
KW - Skin barrier function
KW - Statins
KW - Transepidermal water loss
KW - Water-holding capacity
UR - http://www.scopus.com/inward/record.url?scp=0029988444&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029988444&partnerID=8YFLogxK
M3 - Article
C2 - 8726633
AN - SCOPUS:0029988444
VL - 192
SP - 214
EP - 216
JO - Dermatology
JF - Dermatology
SN - 1018-8665
IS - 3
ER -