Abstract
Background: Topical application of inhibitors of HMGCoA reductase, the rate-limiting enzyme of cholesterol synthesis, has been shown to induce impairment of barrier function. Objective: Assessing whether oral administration of statins used for reducing blood levels of cholesterol induces functional changes in stratum corneum barrier. Materials and Methods: 69 subjects of both sexes undergoing treatment for hypercholesterolemia (mean age 48 ± 11 years) entered the study; 43 had been treated with simvastatin and 11 with pravastatin for 6 months; 15 only on dietary regimen served as controls. Efficiency of stratum corneum water barrier was evaluated by transepidermal water loss (TEWL) measurement using an evaporimeter; water-holding capacity of the stratum corneum was assessed by the sorption-desorption test measured by capacitance. Statistical analysis was performed using ANOVA. Results: No differences were found between the groups (simvastatin, pravastatin, diet) concerning both basal TEWL and the dynamic of water binding in the stratum corneum. Conclusions: Prolonged treatment with cholesterol-lowering drugs based on inhibition of HMGCoA reductase does not alter the permeability barrier of the skin.
Original language | English |
---|---|
Pages (from-to) | 214-216 |
Number of pages | 3 |
Journal | Dermatology |
Volume | 192 |
Issue number | 3 |
Publication status | Published - 1996 |
Keywords
- Cholesterol synthesis
- HMG-CoA reductase
- Skin barrier function
- Statins
- Transepidermal water loss
- Water-holding capacity
ASJC Scopus subject areas
- Dermatology