Effects of telmisartan and amlodipine in combination on ambulatory blood pressure in stages 1-2 hypertension

William B. White, Thomas W. Littlejohn, Claudio R. Majul, Willie Oigman, Rafael Olvera, Mary Seeber, Helmut Schumacher, Giuseppe Mancia

Research output: Contribution to journalArticle

Abstract

Background: Evaluation of combination therapy with antihypertensive agents by clinic blood pressure (BP) measurements may yield results that differ from out-of-office BP readings. This is of clinical relevance because out-of-office BP values are of prognostic importance. We studied the effects of combining telmisartan and amlodipine on ambulatory BP in patients with stages 1-2 hypertension. METHODS: We conducted an 8-week, placebo-controlled, double-blind, 4×4 factorial design trial in which 562 patients with clinic diastolic BP at least 95 and 119mmHg or less were randomized to receive telmisartan (0, 20, 40, or 80mg) and/or amlodipine (0, 2.5, 5, or 10mg). Ambulatory BP monitoring was performed at baseline and after 8 weeks of treatment; the end points of interest were the changes from baseline in 24-h systolic and diastolic BP. Secondary end points included the proportion of responders (≥10mmHg BP reduction from baseline and/or

Original languageEnglish
Pages (from-to)205-212
Number of pages8
JournalBlood Pressure Monitoring
Volume15
Issue number4
DOIs
Publication statusPublished - Aug 2010

Keywords

  • ambulatory blood pressure monitoring
  • amlodipine
  • factorial design trial
  • telmisartan

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Assessment and Diagnosis
  • Advanced and Specialised Nursing
  • Medicine(all)

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  • Cite this

    White, W. B., Littlejohn, T. W., Majul, C. R., Oigman, W., Olvera, R., Seeber, M., Schumacher, H., & Mancia, G. (2010). Effects of telmisartan and amlodipine in combination on ambulatory blood pressure in stages 1-2 hypertension. Blood Pressure Monitoring, 15(4), 205-212. https://doi.org/10.1097/MBP.0b013e32833c5722