Effects of tertatolol on renal function in the isolated perfused rat kidney

Research output: Contribution to journalArticlepeer-review

Abstract

Tertatolol, a new beta-adrenergic blocker, increases glomerular filtration rate (GFR) and renal plasma flow (RPF), and enhances diuresis and natriuresis in experimental animals and humans. The mechanism underlying the renal effects of tertatolol has not been established. In the present study we addressed the possibility that tertatolol influences renal function by a direct intrarenal mechanism. For this purpose we used a preparation of isolated rat kidney perfused with an artificial cell-free medium. Tertatolol when given as a bolus injection into the renal artery at the dose of 25 and 50 µg/kg, but not of 12.5 µg/kg, significantly enhanced the glomerular filtration rate (GFR) and perfusate flow rate (PFR). In contrast, the intrarenal bolus injection of different doses of propranolol (100, 250, or 500 µg/kg) was unable to change GFR and PFR to a significant extent. While no change in urine flow rate was found when the lowest dose of tertatolol was used, the compound at the dose of 25 and 50 µg/kg progressively increased urine flow during the time of perfusion. A similar effect of tertatolol was observed for urinary sodium and potassium excretion. In contrast, different doses of propranolol did not significantly change the urine flow rate or sodium and potassium excretion rates. We conclude that tertatolol, but not propranolol, increases GFR and PFR, and enhances urine output and sodium excretion in the isolated perfused rat kidney. These findings indicate that tertatolol preserves renal function by a mechanism independent of systemic changes. Am J Hypertens 1989; 2: 223S-227S.

Original languageEnglish
Pages (from-to)223S-227S
JournalAmerican Journal of Hypertension
Volume2
Issue number11
DOIs
Publication statusPublished - 1989

Keywords

  • Beta-blocking agents
  • Glomerular filtration rate
  • Isolated perfused kidney
  • Renal vascular resistance

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Effects of tertatolol on renal function in the isolated perfused rat kidney'. Together they form a unique fingerprint.

Cite this