Effects of tetrahydropapaveroline on dopamine and 5 hydroxytryptamine metabolism in rat brain in vivo

P. Livrea, L. Di Reda, A. Giovine, A. Bertolino

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

HVA and 5 HIAA levels have been assayed in the rat brain at different time intervals after acute or chronic i.p. administration of tetrahydropapaveroline (THP), 8 and 60 mg/kg. In addition, the influence of THP pretreatment on the L dopa induced HVA increase in the rat brain as well as the PCPA induced 5 HIAA decrease have been studied. The results support the possibility that THP may displace brain monoamines in vivo. This property of THP may be related to certain side effects of L dopa long term therapy in parkinsonism.

Original languageEnglish
Pages (from-to)20-26
Number of pages7
JournalPharmacology
Volume14
Issue number1
Publication statusPublished - 1976

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Tetrahydropapaveroline
Dopamine
Serotonin
Hydroxyindoleacetic Acid
Brain
Levodopa
Parkinsonian Disorders

ASJC Scopus subject areas

  • Pharmacology

Cite this

Livrea, P., Di Reda, L., Giovine, A., & Bertolino, A. (1976). Effects of tetrahydropapaveroline on dopamine and 5 hydroxytryptamine metabolism in rat brain in vivo. Pharmacology, 14(1), 20-26.

Effects of tetrahydropapaveroline on dopamine and 5 hydroxytryptamine metabolism in rat brain in vivo. / Livrea, P.; Di Reda, L.; Giovine, A.; Bertolino, A.

In: Pharmacology, Vol. 14, No. 1, 1976, p. 20-26.

Research output: Contribution to journalArticle

Livrea, P, Di Reda, L, Giovine, A & Bertolino, A 1976, 'Effects of tetrahydropapaveroline on dopamine and 5 hydroxytryptamine metabolism in rat brain in vivo', Pharmacology, vol. 14, no. 1, pp. 20-26.
Livrea, P. ; Di Reda, L. ; Giovine, A. ; Bertolino, A. / Effects of tetrahydropapaveroline on dopamine and 5 hydroxytryptamine metabolism in rat brain in vivo. In: Pharmacology. 1976 ; Vol. 14, No. 1. pp. 20-26.
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