Effects of tetrahydropapaveroline on dopamine and 5 hydroxytryptamine metabolism in rat brain in vivo

P. Livrea, L. Di Reda, A. Giovine, A. Bertolino

Research output: Contribution to journalArticlepeer-review

Abstract

HVA and 5 HIAA levels have been assayed in the rat brain at different time intervals after acute or chronic i.p. administration of tetrahydropapaveroline (THP), 8 and 60 mg/kg. In addition, the influence of THP pretreatment on the L dopa induced HVA increase in the rat brain as well as the PCPA induced 5 HIAA decrease have been studied. The results support the possibility that THP may displace brain monoamines in vivo. This property of THP may be related to certain side effects of L dopa long term therapy in parkinsonism.

Original languageEnglish
Pages (from-to)20-26
Number of pages7
JournalPharmacology
Volume14
Issue number1
Publication statusPublished - 1976

ASJC Scopus subject areas

  • Pharmacology

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