Abstract
HVA and 5 HIAA levels have been assayed in the rat brain at different time intervals after acute or chronic i.p. administration of tetrahydropapaveroline (THP), 8 and 60 mg/kg. In addition, the influence of THP pretreatment on the L dopa induced HVA increase in the rat brain as well as the PCPA induced 5 HIAA decrease have been studied. The results support the possibility that THP may displace brain monoamines in vivo. This property of THP may be related to certain side effects of L dopa long term therapy in parkinsonism.
| Original language | English |
|---|---|
| Pages (from-to) | 20-26 |
| Number of pages | 7 |
| Journal | Pharmacology |
| Volume | 14 |
| Issue number | 1 |
| Publication status | Published - 1976 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Effects of tetrahydropapaveroline on dopamine and 5 hydroxytryptamine metabolism in rat brain in vivo. / Livrea, P.; Di Reda, L.; Giovine, A.; Bertolino, A.
In: Pharmacology, Vol. 14, No. 1, 1976, p. 20-26.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of tetrahydropapaveroline on dopamine and 5 hydroxytryptamine metabolism in rat brain in vivo
AU - Livrea, P.
AU - Di Reda, L.
AU - Giovine, A.
AU - Bertolino, A.
PY - 1976
Y1 - 1976
N2 - HVA and 5 HIAA levels have been assayed in the rat brain at different time intervals after acute or chronic i.p. administration of tetrahydropapaveroline (THP), 8 and 60 mg/kg. In addition, the influence of THP pretreatment on the L dopa induced HVA increase in the rat brain as well as the PCPA induced 5 HIAA decrease have been studied. The results support the possibility that THP may displace brain monoamines in vivo. This property of THP may be related to certain side effects of L dopa long term therapy in parkinsonism.
AB - HVA and 5 HIAA levels have been assayed in the rat brain at different time intervals after acute or chronic i.p. administration of tetrahydropapaveroline (THP), 8 and 60 mg/kg. In addition, the influence of THP pretreatment on the L dopa induced HVA increase in the rat brain as well as the PCPA induced 5 HIAA decrease have been studied. The results support the possibility that THP may displace brain monoamines in vivo. This property of THP may be related to certain side effects of L dopa long term therapy in parkinsonism.
UR - http://www.scopus.com/inward/record.url?scp=0017293191&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017293191&partnerID=8YFLogxK
M3 - Article
VL - 14
SP - 20
EP - 26
JO - Pharmacology
JF - Pharmacology
SN - 0031-7012
IS - 1
ER -