Effects of tetrahydropapaveroline on dopamine and 5 hydroxytryptamine metabolism in rat brain in vivo

P. Livrea; L. Di Reda; A. Giovine; A. Bertolino

Effects of tetrahydropapaveroline on dopamine and 5 hydroxytryptamine metabolism in rat brain in vivo

P. Livrea, L. Di Reda, A. Giovine, A. Bertolino

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article › peer-review

Abstract

HVA and 5 HIAA levels have been assayed in the rat brain at different time intervals after acute or chronic i.p. administration of tetrahydropapaveroline (THP), 8 and 60 mg/kg. In addition, the influence of THP pretreatment on the L dopa induced HVA increase in the rat brain as well as the PCPA induced 5 HIAA decrease have been studied. The results support the possibility that THP may displace brain monoamines in vivo. This property of THP may be related to certain side effects of L dopa long term therapy in parkinsonism.

Original language	English
Pages (from-to)	20-26
Number of pages	7
Journal	Pharmacology
Volume	14
Issue number	1
Publication status	Published - 1976

ASJC Scopus subject areas

Pharmacology

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title = "Effects of tetrahydropapaveroline on dopamine and 5 hydroxytryptamine metabolism in rat brain in vivo",

abstract = "HVA and 5 HIAA levels have been assayed in the rat brain at different time intervals after acute or chronic i.p. administration of tetrahydropapaveroline (THP), 8 and 60 mg/kg. In addition, the influence of THP pretreatment on the L dopa induced HVA increase in the rat brain as well as the PCPA induced 5 HIAA decrease have been studied. The results support the possibility that THP may displace brain monoamines in vivo. This property of THP may be related to certain side effects of L dopa long term therapy in parkinsonism.",

author = "P. Livrea and {Di Reda}, L. and A. Giovine and A. Bertolino",

year = "1976",

language = "English",

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journal = "Pharmacology",

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T1 - Effects of tetrahydropapaveroline on dopamine and 5 hydroxytryptamine metabolism in rat brain in vivo

AU - Livrea, P.

AU - Di Reda, L.

AU - Giovine, A.

AU - Bertolino, A.

PY - 1976

Y1 - 1976

N2 - HVA and 5 HIAA levels have been assayed in the rat brain at different time intervals after acute or chronic i.p. administration of tetrahydropapaveroline (THP), 8 and 60 mg/kg. In addition, the influence of THP pretreatment on the L dopa induced HVA increase in the rat brain as well as the PCPA induced 5 HIAA decrease have been studied. The results support the possibility that THP may displace brain monoamines in vivo. This property of THP may be related to certain side effects of L dopa long term therapy in parkinsonism.

AB - HVA and 5 HIAA levels have been assayed in the rat brain at different time intervals after acute or chronic i.p. administration of tetrahydropapaveroline (THP), 8 and 60 mg/kg. In addition, the influence of THP pretreatment on the L dopa induced HVA increase in the rat brain as well as the PCPA induced 5 HIAA decrease have been studied. The results support the possibility that THP may displace brain monoamines in vivo. This property of THP may be related to certain side effects of L dopa long term therapy in parkinsonism.

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