Effects of thalamic stroke on energy metabolism of the cerebral cortex†: A positron tomography study in man

J. C. Baron, R. D'antona, P. Pantano, M. Serdaru, Y. Samson, M. G. Bousser

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

Positron emission tomography was used to study the effects of unilateral vascular thalamic lesions on cortical oxygen and glucose utilization in 10 patients. There was significant ipsilateral cortex hypometabolism in 9 of the 10 patients, affecting the whole cortical mantle diffusely. The only patient spared was free of neuropsychological deficit at the time of positron emission tomography. In 4 patients, the magnitude of ipsilateral cortical hypometabolism was significantly less at a follow-up PET study, when neuropsychological function had improved When taken together, the 14 studies showed a significant tendency for the hypometabolism to improve with taken together, the 14 studies showed a significant tendency for the hypometabolism to improve with time after clinical onset. These data suggest that the ipsilateral cortical hypometabolism results from damage to the thalamo-cortical connections and reflect either loss of nonspecific activating afferences or a degenerative deafferentation-deefferentation process, or both. Its links with the concept of diaschisis are suggested by its tendency to recover. A causal relationship between cortical hypometabolism and neuropsychological deficit, however, although strongly suggested, cannot be firmly established from the present data.

Original languageEnglish
Pages (from-to)1243-1259
Number of pages17
JournalBrain
Volume109
Issue number6
DOIs
Publication statusPublished - Dec 1986

Fingerprint

Energy Metabolism
Positron Emission Tomography
Positron emission tomography
cerebral cortex
tomography
Positrons
Cortex
Tomography
Stroke
stroke
Cerebral Cortex
energy metabolism
electrons
Electrons
positron-emission tomography
Glucose
Positron-Emission Tomography
Oxygen
Damage
blood vessels

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Effects of thalamic stroke on energy metabolism of the cerebral cortex† : A positron tomography study in man. / Baron, J. C.; D'antona, R.; Pantano, P.; Serdaru, M.; Samson, Y.; Bousser, M. G.

In: Brain, Vol. 109, No. 6, 12.1986, p. 1243-1259.

Research output: Contribution to journalArticle

Baron, J. C. ; D'antona, R. ; Pantano, P. ; Serdaru, M. ; Samson, Y. ; Bousser, M. G. / Effects of thalamic stroke on energy metabolism of the cerebral cortex† : A positron tomography study in man. In: Brain. 1986 ; Vol. 109, No. 6. pp. 1243-1259.
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