Effects of thalidomide on parameters involved in angiogenesis: An in vitro study

M. Gelati, E. Corsini, S. Frigerio, B. Pollo, G. Broggi, D. Croci, A. Silvani, A. Boiardi, Andrea Salmaggi

Research output: Contribution to journalArticle

Abstract

In an attempt to elucidate the mechanism(s) of action of thalidomide, a reportedly antiangiogenic molecule recently tested in the treatment of relapsing malignant gliomas, we performed an in vitro study on the following parameters: (a) effect of thalidomide on proliferation of endothelial cells; (b) effect of thalidomide on expression of αvβ3 integrin on the surface of endothelial cells; (c) effect of thalidomide on the release by endothelial cells of MMP-2, IL-8 and TNF-α. The results show that thalidomide inhibits endothelial cell proliferation induced by bFGF and VEGF, more so if the cells are grown on vitronectin; moreover, treatment with thalidomide reduces the release of MMP-2 and IL-8 by endothelial cells, suggesting a further pathway for the antiangiogenic activity of drug. On the other hand, thalidomide does not modify expression of αvβ3 on endothelial cells.

Original languageEnglish
Pages (from-to)193-201
Number of pages9
JournalJournal of Neuro-Oncology
Volume64
Issue number3
DOIs
Publication statusPublished - Sep 2003

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Keywords

  • αvβ3
  • Angiogenesis
  • Endothelial proliferation
  • IL-8
  • Malignant glioma
  • MMP-2
  • Thalidomide

ASJC Scopus subject areas

  • Cancer Research
  • Clinical Neurology
  • Oncology
  • Neuroscience(all)

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