Effects of the change from stavudine to tenofovir in human immunodeficiency virus-infected children treated with highly active antiretroviral therapy: Studies on mitochondrial toxicity and thymic function

Raffaella Rosso, Milena Nasi, Antonio Di Biagio, Ernestina Repetto, Chiara Dentone, Marcello Pinti, Elisa Nemes, Roberta Ferraresi, Cristina Mussini, Roberto Esposito, Claudio Viscoli, Andrea Cossarizza

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Changing from drugs that have significant mitochondrial toxicity to less toxic compounds may be of benefit in human immunodeficiency virus (HIV)-positive patients who receive highly active antiretroviral therapy. Few data on mitochondrial toxicity of antiviral drugs are available in HIV-positive children. METHODS: Eighteen HIV-positive children (median age, 10.9 years) receiving a stavudine-containing regimen were randomized to maintain stavudine (arm A) or change to tenofovir (arm B), while preserving the remaining drugs. Glucose, lipidic, and viro-immunologic factors were assessed at months 0, 1, 3, 6, 12, and 18. Thymic output and mtDNA content were measured in peripheral blood mononuclear cells at 0 and 6 months, mtDNA in isolated CD4 and CD8 T cells after 18 months. RESULTS: From baseline to month 6, arms A and B showed similar thymic output and mtDNA. After 18 months, a significant decrease in plasma HDL was observed in arm B, along with a small increase in blood glucose; mtDNA showed no difference. In the 2 arms other factors did not show significant differences from the baseline and from the previous values at 18 months. CONCLUSIONS: Changing from stavudine to tenofovir was well-tolerated, and viro-immunologic success was maintained.

Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalPediatric Infectious Disease Journal
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 2008

Keywords

  • HAART
  • HIV
  • mtDNA
  • Stavudine
  • Tenofovir
  • TREC

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)

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