Effects of the Combination of Low-Dose Nifedipine GITS 20 mg and Losartan 50 mg in Patients with Mild to Moderate Hypertension

Emilio Kuschnir, Mario Bendersky, Jorge Resk, Maria Silva Pañart, Luiz Guzman, Yankel Plotquin, Guido Grassi, Giuseppe Mancia, Gilbert Wagener

Research output: Contribution to journalArticle

Abstract

Most hypertensive patients require more than one medication to effectively control elevated blood pressure (BP) values. This multicenter, randomized, double-blind study was aimed at testing the efficacy and safety of the combination of low-dose nifedipine GITS 20 mg/losartan 50 mg compared with either monotherapy in patients with grade 1 to 3 hypertension over an eight-week period. Of 352 patients enrolled in the study, 300 were randomized. All the three treatments lowered elevated BP without clinically relevant changes in heart rate. All the three treatments lowered mean 24-hour diastolic BP: nifedipine GITS/losartan -10.6 mm Hg, losartan -5.4 mm Hg, nifedipine GITS 20 mg -8.0 mm Hg. There was a statistically significant difference of diastolic BP change between patients receiving losartan compared with those receiving combination treatment (P <0.05). Diastolic BP trough-to-peak ratio and smoothness index were highest in the patient group receiving combination therapy (70%). Nifedipine GITS monotherapy had the highest systolic BP trough-to-peak ratio of all treatment arms (78%) and higher diastolic BP trough-to-peak ratio and smoothness index than losartan monotherapy. All treatments were safe. These data provide evidence that in hypertensive patients combination of nifedipine GITS 20 mg and losartan 50 mg improves control of systolic and diastolic BP compared with either monotherapy.

Original languageEnglish
Pages (from-to)300-305
Number of pages6
JournalJournal of Cardiovascular Pharmacology
Volume43
Issue number2
DOIs
Publication statusPublished - Feb 2004

Keywords

  • Ambulatory blood pressure monitoring
  • Combination treatment
  • Losartan
  • Nifedipine GITS

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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