Effects of the NMDA-antagonist, MK-801, on stress-induced alterations of dopamine dependent behavior

Andrea Mele, Simona Cabib, Alberto Oliverio

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of pretreatment with the non-competitive NMDA antagonist (+)MK-801 on the behavioral alterations induced by repeated restraint stress were investigated. Repeatedly stressed (restraint stress 2 h a day × 10 days) mice showed enhanced sensitivity to the inhibitory effects of a low dose of direct dopamine agonist, apomorphine (0.25 mg/kg), on climbing behavior. On the other hand, no changes were observed for the stimulatory effect of the high dose of apomorphine (3 mg/kg) on this behavioral response. Mice pretreated with MK-801 (0.15 mg/kg) before the stressful experience did not show altered response to the low dose of apomorphine (0.25 mg/kg). Finally, ten daily injections with 0.15 mg/kg MK-801 did not affect the behavioral response to the low dose of apomorphine, but enhanced the stimulatory effect of the high dose of the dopaminergic agonist on climbing behavior. Therefore, it is possible that the protective action of MK-801 against stress-induced behavioral alteration is due to changes in sensitivity of postsynaptic receptors.

Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalPsychopharmacology
Volume117
Issue number3
DOIs
Publication statusPublished - Feb 1995

Keywords

  • Apomorphine
  • Chronic stress
  • Climbing behaviour
  • Dopamine
  • Glutamate
  • MK801
  • Mouse

ASJC Scopus subject areas

  • Pharmacology

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