Effects of the novel acetylcholinesterase inhibitor N-octyl-1,2,3,4- tetrahydro-9-aminoacridine on locomotor activity and avoidance learning in mice

Francesca Capone, Alberto Oliverio, Massimo Pomponi, Maurizio Marta, Franco Gatta, Flaminia Pavone

Research output: Contribution to journalArticle

Abstract

The acetylcholinesterase reversible inhibitor N-octyl-1,2,3,4- tetrahydro-9-aminoacridine (THA-C8) is a new synthesized derivative of tacrine (THA) characterized by an alkyl chain in the molecular structure which ameliorates the penetrability of the compound into the central nervous system. THA-C8 (0.1-5 mg/kg) significantly reduced spontaneous locomotor activity in CD1 mice at a dose of 3 mg/kg. Moreover, THA-C8 (0.2-2 mg/kg) significantly improved shuttle-box avoidance acquisition at doses (0.25, 0.3, 1 mg/kg) not affecting locomotion and that are much lower than the doses reported to be effective for THA in animal models. From the data reported it seems that the new compound could be interesting for therapeutic purposes.

Original languageEnglish
Pages (from-to)301-307
Number of pages7
JournalNeurobiology of Learning and Memory
Volume71
Issue number3
DOIs
Publication statusPublished - May 1999

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Keywords

  • Acetylcholinesterase inhibitor
  • Active avoidance
  • Locomotor activity
  • Mice
  • Tacrine
  • THA-C8

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

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