Effetti di un agonista dopaminergico parziale, terguride, sul dotto deferente elettrostimolato di topo.

Translated title of the contribution: Effects of the partial dopamine receptor agonist, terguride, on the field-stimulated vas deferens in the mouse

M. R. Carratù, A. De Serio, R. Lagioia, D. Conte-Camerino, E. Ferrari, D. Mitolo-Chieppa

Research output: Contribution to journalArticle

Abstract

Transdihydrolisuride (terguride), a 9,10-dihydrogenated analogue of the ergot dopamine agonist lisuride, is characterized as partial dopamine receptor agonist at CNS level. This compound was investigated for its effects on peripheral neurotransmission in the attempt to delineate its pharmacological profile. The contractile responses of field-stimulated mouse vas deferens were slightly inhibited by terguride at very high concentrations (10(-5)-10(-2) M); the selective antagonists for alpha 2-adrenergic and dopamine receptors failed to counteract this effect. Terguride was very effective in blocking the inhibitory effects of LY 171555 (selective DA2 agonist), SK&F 38393 (selective DA1 agonist) and clonidine (selective alpha 2 agonist). In no case the antagonism was competitive: the control dose-response curves were not shifted in a parallel and dose-dependent manner. Therefore terguride displays a mixed DA1, DA2 and alpha 2 antagonistic activity.

Original languageItalian
Pages (from-to)35-42
Number of pages8
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume66
Issue number1
Publication statusPublished - Jan 1990

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Vas Deferens
Dopamine Agonists
4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrzolo(3,4-g)quinoline
Lisuride
Adrenergic alpha-2 Receptors
Dopamine Receptors
Clonidine
Synaptic Transmission
dironyl
Pharmacology

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effetti di un agonista dopaminergico parziale, terguride, sul dotto deferente elettrostimolato di topo. / Carratù, M. R.; De Serio, A.; Lagioia, R.; Conte-Camerino, D.; Ferrari, E.; Mitolo-Chieppa, D.

In: Bollettino della Societa Italiana di Biologia Sperimentale, Vol. 66, No. 1, 01.1990, p. 35-42.

Research output: Contribution to journalArticle

Carratù, M. R. ; De Serio, A. ; Lagioia, R. ; Conte-Camerino, D. ; Ferrari, E. ; Mitolo-Chieppa, D. / Effetti di un agonista dopaminergico parziale, terguride, sul dotto deferente elettrostimolato di topo. In: Bollettino della Societa Italiana di Biologia Sperimentale. 1990 ; Vol. 66, No. 1. pp. 35-42.
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