Effects of the single and repeated administration of benazepril on systemic and forearm circulation and cardiac function in hypertensive patients

Nicola De Luca, Stefano Savonitto, Bruno Ricciardelli, Raffaele Marchegiano, Fausto Lamenza, Giuseppe Lembo, Bruno Trimarco

Research output: Contribution to journalArticlepeer-review

Abstract

The hemodynamic and cardiac effects of the new angiotensin-converting enzyme inhibitor, benazepril, were studied in 28 hypertensives in a double blind, placebo-controlled, between-patient study. Hemodynamic studies were performed noninvasively by means of M-mode echo (central hemodynamics and left ventricular systolic function), 2-D echo-Doppler (left ventricular diastolic function), and pulsed Doppler flowmetry (forearm circulation). Examinations were done at the end of a placebo run-in period and 3 hours after benazepril administration, both on the first day and after 6 weeks of treatment (10 or 20 mg once daily, according to patient response). In comparison with placebo, benazepril reduced systolic (p=0.04) and diastolic (p=0.003) blood pressure, because of a significant reduction in systemic vascular resistance (p=0.03), while cardiac output was unchanged. Forearm vascular resistance was reduced and brachial artery compliance increased, although not to a statistically significant level (both p=0.07). Both systolic and diastolic left ventricular function were positively influenced by the afterload reduction: End-systolic stress was reduced by 12% (p=0.07), as was the late diastolic peak flow velocity (p=0.02). All hemodynamic changes were evident after acute benazepril administration, and no difference was observed between acute and repeated treatment. We conclude that, similar to other ACE-inhibitors, benazepril reduces blood pressure through a reduction in vascular resistance, while cardiac output and heart rate are unaffected. These hemodynamic effects occur as early as after the first administration and exert a favorable influence on left ventricular dynamics.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalCardiovascular Drugs and Therapy
Volume7
Issue number2
DOIs
Publication statusPublished - Apr 1993

Keywords

  • benazepril
  • cardiac effects
  • hemodynamics
  • hypertension

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Cardiology and Cardiovascular Medicine

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