Effects of thiabendazole in Mansonella perstans filariasis

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Abstract

Mansonella perstans is a human filarial parasite distributed across the center of Africa and equatorial America. Although M. perstans infection is asymptomatic in most individuals, a variety of symptoms have been described, including angioedema, pruritus, fever, ocular involvement, and serous cavities pain. Eosinophilia is found in many cases. Treatment with diethyl-carbamazine or mebendazole is often ineffective. We present a study on the effects of thiabendazole in the treatment of symptomatic M. perstans filariasis. Twenty-five patients were treated with thiabendazole at a single dose of 50 mg/kg for children and 3 g for adults. Sixteen out of 25 subjects repeated a second dose a week later. Parasite density, eosinophilia, and symptoms were significantly reduced after both one and two-step therapy in most patients. This study shows that thiabendazole may be effective in M. perstans infection. More studies are needed to determine a more effective dosage, or a putative combination treatment.

Original languageEnglish
Pages (from-to)151-153
Number of pages3
JournalParassitologia
Volume45
Issue number3-4
Publication statusPublished - Dec 2003

Keywords

  • Chad
  • Filariasis
  • Mansonella perstans
  • Thiabendazole

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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