Abstract
Mansonella perstans is a human filarial parasite distributed across the center of Africa and equatorial America. Although M. perstans infection is asymptomatic in most individuals, a variety of symptoms have been described, including angioedema, pruritus, fever, ocular involvement, and serous cavities pain. Eosinophilia is found in many cases. Treatment with diethyl-carbamazine or mebendazole is often ineffective. We present a study on the effects of thiabendazole in the treatment of symptomatic M. perstans filariasis. Twenty-five patients were treated with thiabendazole at a single dose of 50 mg/kg for children and 3 g for adults. Sixteen out of 25 subjects repeated a second dose a week later. Parasite density, eosinophilia, and symptoms were significantly reduced after both one and two-step therapy in most patients. This study shows that thiabendazole may be effective in M. perstans infection. More studies are needed to determine a more effective dosage, or a putative combination treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 151-153 |
| Number of pages | 3 |
| Journal | Parassitologia |
| Volume | 45 |
| Issue number | 3-4 |
| Publication status | Published - Dec 2003 |
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Keywords
- Chad
- Filariasis
- Mansonella perstans
- Thiabendazole
ASJC Scopus subject areas
- Immunology and Microbiology(all)
Cite this
Effects of thiabendazole in Mansonella perstans filariasis. / Bregani, E. R.; Rovellini, A.; Tarsia, P.
In: Parassitologia, Vol. 45, No. 3-4, 12.2003, p. 151-153.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of thiabendazole in Mansonella perstans filariasis
AU - Bregani, E. R.
AU - Rovellini, A.
AU - Tarsia, P.
PY - 2003/12
Y1 - 2003/12
N2 - Mansonella perstans is a human filarial parasite distributed across the center of Africa and equatorial America. Although M. perstans infection is asymptomatic in most individuals, a variety of symptoms have been described, including angioedema, pruritus, fever, ocular involvement, and serous cavities pain. Eosinophilia is found in many cases. Treatment with diethyl-carbamazine or mebendazole is often ineffective. We present a study on the effects of thiabendazole in the treatment of symptomatic M. perstans filariasis. Twenty-five patients were treated with thiabendazole at a single dose of 50 mg/kg for children and 3 g for adults. Sixteen out of 25 subjects repeated a second dose a week later. Parasite density, eosinophilia, and symptoms were significantly reduced after both one and two-step therapy in most patients. This study shows that thiabendazole may be effective in M. perstans infection. More studies are needed to determine a more effective dosage, or a putative combination treatment.
AB - Mansonella perstans is a human filarial parasite distributed across the center of Africa and equatorial America. Although M. perstans infection is asymptomatic in most individuals, a variety of symptoms have been described, including angioedema, pruritus, fever, ocular involvement, and serous cavities pain. Eosinophilia is found in many cases. Treatment with diethyl-carbamazine or mebendazole is often ineffective. We present a study on the effects of thiabendazole in the treatment of symptomatic M. perstans filariasis. Twenty-five patients were treated with thiabendazole at a single dose of 50 mg/kg for children and 3 g for adults. Sixteen out of 25 subjects repeated a second dose a week later. Parasite density, eosinophilia, and symptoms were significantly reduced after both one and two-step therapy in most patients. This study shows that thiabendazole may be effective in M. perstans infection. More studies are needed to determine a more effective dosage, or a putative combination treatment.
KW - Chad
KW - Filariasis
KW - Mansonella perstans
KW - Thiabendazole
UR - http://www.scopus.com/inward/record.url?scp=4444356438&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4444356438&partnerID=8YFLogxK
M3 - Article
C2 - 15267104
AN - SCOPUS:4444356438
VL - 45
SP - 151
EP - 153
JO - Parassitologia
JF - Parassitologia
SN - 0048-2951
IS - 3-4
ER -