Effects of three immunosuppressive regimens on vertebral bone density in renal transplant recipients: A prospective study

Adriana Aroldi, Antonio Tarantino, Giuseppe Montagnino, Bruno Cesana, Carlo Cocucci, Claudio Ponticelli

Research output: Contribution to journalArticlepeer-review

Abstract

The influence of three different immunosuppressive regimens with cyclosporine (CsA) on the development of osteopenia in renal transplant patients was assessed. Fifty-three adults with first kidney transplants participated in a randomized trial to analyze the efficacy of three different immunosuppressive regimens: CsA alone (group 1), CsA plus steroids (group 2), and CsA plus steroids plus azathioprine (group 3). Lumbar spine bone mineral density was assessed by dual energy x-ray absorptiometry every 6 months for 18 months. The values for trabecular mass were expressed as bone mineral density and as a fraction of the standard deviation of the mean of the normal value for patient's sex and decade of age (Z-score). Statistical analysis was performed on Z-score and 'Z-score change' (value after 6 months minus the basal value at transplantation). At the 18th month, the Z-score increased significantly in treatment group 1 without steroids (P=0.006) and decreased significantly in steroid-treated groups 2 (P

Original languageEnglish
Pages (from-to)380-386
Number of pages7
JournalTransplantation
Volume63
Issue number3
DOIs
Publication statusPublished - Feb 15 1997

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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