Abstract
Synopsis Sensitive skin is a dermatological problem of increasing incidence in western countries and is sometimes associated with atopic condition and bacterial sovrainfection. The purpose of this study is to evaluate in a double blind, randomized, placebo controlled trial the efficacy of gluco- oligosaccharide and collagen tripeptide F in controlling the signs and symptoms of sensitive atopic skin. Forty female subjects (age, 30-59 years) affected by non-lesional atopic sensitive skin entered the study. Skin sensitivity was determined by a dermatologist on the basis of medical history, stinging test, dermatological examination and a questionnaire. A treatment with the test products (active and placebo) was carried out for 4 weeks. Measurements and clinical evaluation were carried out at baseline and at the end of the study. The following objective parameters investigated were bacterial count, skin pH and colour, transepidermal water loss (TEWL), stratum corneum hydration, skin roughness and mechanical properties. Clinical assessment included also a scoring system for dryness, desquamation, irritation, erythema and papules. Significant differences were found in the active treated group when compared with the placebo and in particular for instrumental parameters of roughness (P <0.02), volume (P <0.01), TEWL (P <0.02), erythema (P <0.0006) and clinical parameters of dryness, desquamation and irritation (P <0.001). Moisturization levels and skin colour improved significantly in both the active and placebo groups. In conclusion, the study shows that the modulation of bacterial proliferation and normalization of skin barrier properties and stratum corneum moisturization can improve the symptoms of sensitive skin.
| Original language | English |
|---|---|
| Pages (from-to) | 271-277 |
| Number of pages | 7 |
| Journal | International Journal of Cosmetic Science |
| Volume | 31 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 2009 |
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Keywords
- Collagen tripeptide
- Gluco-oligosaccharide
- Moisturization
- Sensitive skin
- Skin barrier
- Transepidermal water loss
ASJC Scopus subject areas
- Dermatology
- Colloid and Surface Chemistry
- Ageing
- Drug Discovery
- Pharmaceutical Science
- Chemistry (miscellaneous)
Cite this
Effects of topical gluco-oligosaccharide and collagen tripeptide F in the treatment of sensitive atopic skin. / Berardesca, E.; Abril, E.; Serio, M.; Cameli, N.
In: International Journal of Cosmetic Science, Vol. 31, No. 4, 08.2009, p. 271-277.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of topical gluco-oligosaccharide and collagen tripeptide F in the treatment of sensitive atopic skin
AU - Berardesca, E.
AU - Abril, E.
AU - Serio, M.
AU - Cameli, N.
PY - 2009/8
Y1 - 2009/8
N2 - Synopsis Sensitive skin is a dermatological problem of increasing incidence in western countries and is sometimes associated with atopic condition and bacterial sovrainfection. The purpose of this study is to evaluate in a double blind, randomized, placebo controlled trial the efficacy of gluco- oligosaccharide and collagen tripeptide F in controlling the signs and symptoms of sensitive atopic skin. Forty female subjects (age, 30-59 years) affected by non-lesional atopic sensitive skin entered the study. Skin sensitivity was determined by a dermatologist on the basis of medical history, stinging test, dermatological examination and a questionnaire. A treatment with the test products (active and placebo) was carried out for 4 weeks. Measurements and clinical evaluation were carried out at baseline and at the end of the study. The following objective parameters investigated were bacterial count, skin pH and colour, transepidermal water loss (TEWL), stratum corneum hydration, skin roughness and mechanical properties. Clinical assessment included also a scoring system for dryness, desquamation, irritation, erythema and papules. Significant differences were found in the active treated group when compared with the placebo and in particular for instrumental parameters of roughness (P <0.02), volume (P <0.01), TEWL (P <0.02), erythema (P <0.0006) and clinical parameters of dryness, desquamation and irritation (P <0.001). Moisturization levels and skin colour improved significantly in both the active and placebo groups. In conclusion, the study shows that the modulation of bacterial proliferation and normalization of skin barrier properties and stratum corneum moisturization can improve the symptoms of sensitive skin.
AB - Synopsis Sensitive skin is a dermatological problem of increasing incidence in western countries and is sometimes associated with atopic condition and bacterial sovrainfection. The purpose of this study is to evaluate in a double blind, randomized, placebo controlled trial the efficacy of gluco- oligosaccharide and collagen tripeptide F in controlling the signs and symptoms of sensitive atopic skin. Forty female subjects (age, 30-59 years) affected by non-lesional atopic sensitive skin entered the study. Skin sensitivity was determined by a dermatologist on the basis of medical history, stinging test, dermatological examination and a questionnaire. A treatment with the test products (active and placebo) was carried out for 4 weeks. Measurements and clinical evaluation were carried out at baseline and at the end of the study. The following objective parameters investigated were bacterial count, skin pH and colour, transepidermal water loss (TEWL), stratum corneum hydration, skin roughness and mechanical properties. Clinical assessment included also a scoring system for dryness, desquamation, irritation, erythema and papules. Significant differences were found in the active treated group when compared with the placebo and in particular for instrumental parameters of roughness (P <0.02), volume (P <0.01), TEWL (P <0.02), erythema (P <0.0006) and clinical parameters of dryness, desquamation and irritation (P <0.001). Moisturization levels and skin colour improved significantly in both the active and placebo groups. In conclusion, the study shows that the modulation of bacterial proliferation and normalization of skin barrier properties and stratum corneum moisturization can improve the symptoms of sensitive skin.
KW - Collagen tripeptide
KW - Gluco-oligosaccharide
KW - Moisturization
KW - Sensitive skin
KW - Skin barrier
KW - Transepidermal water loss
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U2 - 10.1111/j.1468-2494.2009.00495.x
DO - 10.1111/j.1468-2494.2009.00495.x
M3 - Article
VL - 31
SP - 271
EP - 277
JO - International Journal of Cosmetic Science
JF - International Journal of Cosmetic Science
SN - 0142-5463
IS - 4
ER -