In our study we evaluated the effects of topiramate (TPM) on interictal epileptiform abnormalities (IEA) and background activity by means of a computerized EEG analysis, in twenty-four adult patients affected by symptomatic or cryptogenic focal epilepsy, with or without secondarily generalization, treated with TPM as adjunctive therapy or monotherapy. Quantitative and qualitative analysis of IEA showed a strong inhibitory effect of TPM on IEA, probably acting on the generating processes. Finally, TPM addition induced a significant reduction of seizures with only minimal interferences with EEG background activity.
|Number of pages||3|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - Jul 2003|
ASJC Scopus subject areas
- Clinical Neurology