Topiramato: Effetti sulle anomalie epilettiformi intercritiche e sull'attività EEG di fondo

Translated title of the contribution: Effects of Topiramate on interictal epileptiform abnormalities and background activity in focal epilepsy

F. Placidi, M. Tombini, A. Romigi, L. Bianchi, F. Izzi, F. Sperli, R. De Simone, D. Mattia, M. G. Marciani

Research output: Contribution to journalArticle

Abstract

In our study we evaluated the effects of topiramate (TPM) on interictal epileptiform abnormalities (IEA) and background activity by means of a computerized EEG analysis, in twenty-four adult patients affected by symptomatic or cryptogenic focal epilepsy, with or without secondarily generalization, treated with TPM as adjunctive therapy or monotherapy. Quantitative and qualitative analysis of IEA showed a strong inhibitory effect of TPM on IEA, probably acting on the generating processes. Finally, TPM addition induced a significant reduction of seizures with only minimal interferences with EEG background activity.

Original languageItalian
Pages (from-to)195-197
Number of pages3
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number121-122
Publication statusPublished - Jul 2003

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ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Placidi, F., Tombini, M., Romigi, A., Bianchi, L., Izzi, F., Sperli, F., De Simone, R., Mattia, D., & Marciani, M. G. (2003). Topiramato: Effetti sulle anomalie epilettiformi intercritiche e sull'attività EEG di fondo. Bollettino - Lega Italiana contro l'Epilessia, (121-122), 195-197.