Topiramate is a novel antiepileptic drug with a therapeutic profile similar to that of carbamazepine and valproate. In order to identify the mechanisms of action of this new, drug, electrophysiological recordings were performed to study the effects of topiramate on Na+ voltage-dependent ionic fluxes in cultured cerebellum granules (Levi et al, 1984) using the patch- clamp technique in whole-cell configuration (Hamill et al, 1981). The data presented indicate topiramateis modulatory activity on Na+ fluxes, thus suggesting one of the possible mechanisms of action that determine topiramateis anticonvulsant effect.
|Translated title of the contribution||Effects of topiramate on Na+ voltage-dependent currents in cultured cerebellar granule cells|
|Number of pages||3|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1996|
ASJC Scopus subject areas
- Clinical Neurology