Effects of transcranial magnetic stimulation during voluntary and non-voluntary stepping movements in humans

I. A. Solopova, V. A. Selionov, O. V. Kazennikov, Y. P. Ivanenko

Research output: Contribution to journalArticle

Abstract

Here, we compared motor evoked potentials (MEP) in response to transcranial magnetic stimulation of the motor cortex and the H-reflex during voluntary and vibration-induced air-stepping movements in humans. Both the MEPs (in mm biceps femoris, rectus femoris and tibialis anterior) and H-reflex (in m soleus) were significantly smaller during vibration-induced cyclic leg movements at matched amplitudes of angular motion and muscle activity. These findings highlight differences between voluntary and non-voluntary activation of the spinal pattern generator circuitry in humans, presumably due to an extra facilitatory effect of voluntary control/triggering of stepping on spinal motoneurons and interneurons. The results support the idea of active engagement of supraspinal motor areas in developing central pattern generator-modulating therapies.

Original languageEnglish
Pages (from-to)64-69
Number of pages6
JournalNeuroscience Letters
Volume579
DOIs
Publication statusPublished - Sep 5 2014

Keywords

  • Air-stepping
  • Central pattern generator
  • H-reflex
  • Humans
  • Motor cortex
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

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