Trazodone. a novel antidepressant with a structure different from the tricyclic compounds. inhibits the release of brain 5-HT induced by fenfluramine and blocks the uptake of 5-HT by rat platelets. Two known metabolites of trazodone. oxatriazolepyridin propionic acid and trazodone-N-oxide. do not share the properties of trazodone. A suggested hut unproven metabolite of trazodone. m-chlorophenyl piperazine. is however more active than trazodone as an inhibitor of 5-HT uptake. Trazodone and its derivatives are devoid of activity as releasers of 5-HT from rat platelets.
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