Trazodone, a novel antidepressant with a structure different from the tricyclic compounds, inhibits the release of brain 5 HT induced by fenfluramine and blocks the uptake of 5 HT by rat platelets. Two known metabolites of trazodone, oxatriazolepyridin propionic acid and trazodone N oxide, do not share the properties of trazodone. A suggested but unproven metabolite of trazodone, m chlorophenyl piperazine, is however more active than trazodone as an inhibitor of 5 HT uptake. Trazodone and its derivatives are devoid of activity as releasers of 5 HT from rat platelets.
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