Effects of trazodone on serotonin in the brain and platelets of the rat

S. Garattini, G. de Gaetano, R. Samanin, S. Bernasconi, M. C. Roncaglioni

Research output: Contribution to journalArticle

Abstract

Trazodone, a novel antidepressant with a structure different from the tricyclic compounds, inhibits the release of brain 5 HT induced by fenfluramine and blocks the uptake of 5 HT by rat platelets. Two known metabolites of trazodone, oxatriazolepyridin propionic acid and trazodone N oxide, do not share the properties of trazodone. A suggested but unproven metabolite of trazodone, m chlorophenyl piperazine, is however more active than trazodone as an inhibitor of 5 HT uptake. Trazodone and its derivatives are devoid of activity as releasers of 5 HT from rat platelets.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalBiochemical Pharmacology
Volume25
Issue number1
DOIs
Publication statusPublished - 1976

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Trazodone
Platelets
Rats
Brain
Serotonin
Blood Platelets
Metabolites
Fenfluramine
Serotonin Uptake Inhibitors
Oxides
Antidepressive Agents
Derivatives

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of trazodone on serotonin in the brain and platelets of the rat. / Garattini, S.; de Gaetano, G.; Samanin, R.; Bernasconi, S.; Roncaglioni, M. C.

In: Biochemical Pharmacology, Vol. 25, No. 1, 1976, p. 13-16.

Research output: Contribution to journalArticle

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