Abstract
Trazodone, a novel antidepressant with a structure different from the tricyclic compounds, inhibits the release of brain 5 HT induced by fenfluramine and blocks the uptake of 5 HT by rat platelets. Two known metabolites of trazodone, oxatriazolepyridin propionic acid and trazodone N oxide, do not share the properties of trazodone. A suggested but unproven metabolite of trazodone, m chlorophenyl piperazine, is however more active than trazodone as an inhibitor of 5 HT uptake. Trazodone and its derivatives are devoid of activity as releasers of 5 HT from rat platelets.
| Original language | English |
|---|---|
| Pages (from-to) | 13-16 |
| Number of pages | 4 |
| Journal | Biochemical Pharmacology |
| Volume | 25 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1976 |
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ASJC Scopus subject areas
- Pharmacology
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Effects of trazodone on serotonin in the brain and platelets of the rat. / Garattini, S.; de Gaetano, G.; Samanin, R.; Bernasconi, S.; Roncaglioni, M. C.
In: Biochemical Pharmacology, Vol. 25, No. 1, 1976, p. 13-16.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of trazodone on serotonin in the brain and platelets of the rat
AU - Garattini, S.
AU - de Gaetano, G.
AU - Samanin, R.
AU - Bernasconi, S.
AU - Roncaglioni, M. C.
PY - 1976
Y1 - 1976
N2 - Trazodone, a novel antidepressant with a structure different from the tricyclic compounds, inhibits the release of brain 5 HT induced by fenfluramine and blocks the uptake of 5 HT by rat platelets. Two known metabolites of trazodone, oxatriazolepyridin propionic acid and trazodone N oxide, do not share the properties of trazodone. A suggested but unproven metabolite of trazodone, m chlorophenyl piperazine, is however more active than trazodone as an inhibitor of 5 HT uptake. Trazodone and its derivatives are devoid of activity as releasers of 5 HT from rat platelets.
AB - Trazodone, a novel antidepressant with a structure different from the tricyclic compounds, inhibits the release of brain 5 HT induced by fenfluramine and blocks the uptake of 5 HT by rat platelets. Two known metabolites of trazodone, oxatriazolepyridin propionic acid and trazodone N oxide, do not share the properties of trazodone. A suggested but unproven metabolite of trazodone, m chlorophenyl piperazine, is however more active than trazodone as an inhibitor of 5 HT uptake. Trazodone and its derivatives are devoid of activity as releasers of 5 HT from rat platelets.
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U2 - 10.1016/0006-291X(76)90022-X
DO - 10.1016/0006-291X(76)90022-X
M3 - Article
C2 - 1252251
VL - 25
SP - 13
EP - 16
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
SN - 0006-2952
IS - 1
ER -