Effects of treatment with rhGH on erythropoiesis in adults with hypopituitarism

A. Ardizzi, G. Grugni, A. Sartorio, G. Guzzaloni, D. Moro, F. Morabito

Research output: Contribution to journalArticlepeer-review

Abstract

Many factors are implicated in the regulation of erythropoiesis; one such compound might be GH with the direct or indirect involvement of IGF-1 or of erythropoietin. This study examines the effects of GH on erythropoiesis in a series of eight adults with IGHD by assaying variations of values referred to a blood test before and after 6 months of treatment with rhGH at 0.4 IU/Kg/week. Results indicate a significant increase in RBC (p <0.04) and PLT (p <0.008) and a reduction in the values of MCV, MCH and MCHC. We conclude GH influences erythropoiesis even if the underlying mechanism is still unknown.

Original languageEnglish
Pages (from-to)79-82
Number of pages4
JournalActa Medica Auxologica
Volume27
Issue number2-3
Publication statusPublished - 1995

Keywords

  • erythropoiesis
  • GH
  • IGHD

ASJC Scopus subject areas

  • Medicine(all)

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