Effects of TRH-T on spinal motoneurones in man

Rocco Raffaele, Emanuele Cosentino, Maria B. Anicito, Alfio Sciacca, Liborio Rampello, Giovanni Pennisi, Armando A. Genazzani, Gianfranco Bosco, Antonino Casabona, Filippo Drago

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effect of thyrotropin-releasing hormone tartrate (TRH-T) on the decrease in H Max/M Max ratio, an index of the spinal motoneurone pool, induced by haloperidol, was studied in 15 healthy volunteers. In all subjects, the H response was examined by an electromyographic apparatus. The values were expressed as H Max/M Max ratio, that gives an index of excitability of the spinal motoneurone pool. It was found that the mean H Max/M Max ratio value significantly decreased after haloperidol administration, but this effect was completely reversed by the injection of TRH-T. This finding suggests that the peptide may modulate motoneurone functions.

Original languageEnglish
Pages (from-to)1017-1018
Number of pages2
JournalNeuroReport
Volume3
Issue number11
Publication statusPublished - 1992

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Thyrotropin-Releasing Hormone
Motor Neurons
Haloperidol
Healthy Volunteers
Peptides
Injections

Keywords

  • Haloperidol
  • Spinal motoneurone pool
  • Thyrotropin-releasing hormone

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Raffaele, R., Cosentino, E., Anicito, M. B., Sciacca, A., Rampello, L., Pennisi, G., ... Drago, F. (1992). Effects of TRH-T on spinal motoneurones in man. NeuroReport, 3(11), 1017-1018.

Effects of TRH-T on spinal motoneurones in man. / Raffaele, Rocco; Cosentino, Emanuele; Anicito, Maria B.; Sciacca, Alfio; Rampello, Liborio; Pennisi, Giovanni; Genazzani, Armando A.; Bosco, Gianfranco; Casabona, Antonino; Drago, Filippo.

In: NeuroReport, Vol. 3, No. 11, 1992, p. 1017-1018.

Research output: Contribution to journalArticle

Raffaele, R, Cosentino, E, Anicito, MB, Sciacca, A, Rampello, L, Pennisi, G, Genazzani, AA, Bosco, G, Casabona, A & Drago, F 1992, 'Effects of TRH-T on spinal motoneurones in man', NeuroReport, vol. 3, no. 11, pp. 1017-1018.
Raffaele R, Cosentino E, Anicito MB, Sciacca A, Rampello L, Pennisi G et al. Effects of TRH-T on spinal motoneurones in man. NeuroReport. 1992;3(11):1017-1018.
Raffaele, Rocco ; Cosentino, Emanuele ; Anicito, Maria B. ; Sciacca, Alfio ; Rampello, Liborio ; Pennisi, Giovanni ; Genazzani, Armando A. ; Bosco, Gianfranco ; Casabona, Antonino ; Drago, Filippo. / Effects of TRH-T on spinal motoneurones in man. In: NeuroReport. 1992 ; Vol. 3, No. 11. pp. 1017-1018.
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