Effects of TRH-T on spinal motoneurones in man

Rocco Raffaele, Emanuele Cosentino, Maria B. Anicito, Alfio Sciacca, Liborio Rampello, Giovanni Pennisi, Armando A. Genazzani, Gianfranco Bosco, Antonino Casabona, Filippo Drago

Research output: Contribution to journalArticle

Abstract

The effect of thyrotropin-releasing hormone tartrate (TRH-T) on the decrease in H Max/M Max ratio, an index of the spinal motoneurone pool, induced by haloperidol, was studied in 15 healthy volunteers. In all subjects, the H response was examined by an electromyographic apparatus. The values were expressed as H Max/M Max ratio, that gives an index of excitability of the spinal motoneurone pool. It was found that the mean H Max/M Max ratio value significantly decreased after haloperidol administration, but this effect was completely reversed by the injection of TRH-T. This finding suggests that the peptide may modulate motoneurone functions.

Original languageEnglish
Pages (from-to)1017-1018
Number of pages2
JournalNeuroReport
Volume3
Issue number11
Publication statusPublished - 1992

Keywords

  • Haloperidol
  • Spinal motoneurone pool
  • Thyrotropin-releasing hormone

ASJC Scopus subject areas

  • Neuroscience(all)

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