Effects of triacetyloleandomycin on the ultrastructure of the rat liver. II. Late high dose effects

E. Garaci, W. Djaczenko, E. Genazzani

Research output: Chapter in Book/Report/Conference proceedingChapter


The late effects of a single high dose (800 mg/kg b.w.) administration of TAO (36 hr and 48 hr after administration) on liver ultrastructure was defined as a persisting alteration of the chromatin of the hepatocytes, which was visible at 36 hr as an accumulation of 160-200 A granules of medium electron opacity. Nucleoli were preserved with typical normal structure and a high contrast. At 36 hr large cytoplasmic zones occupied by proliferated SER profiles (some with a quasi crystalline array) were still visible. The number of lipid inclusions at 36 hr had increased in comparison with the 24 hr stage. The mitochondria of the experimental hepatocytes were larger than at 24 hr. High dose (800 mg/kg b.w.) effects of TAO at 48 hr after administration were defined as follows: there was a higher frequency of chromatin clumps in the hepatocyte nuclei which were similar to those observed in control material, than at 36 hr. At 48 hr cytoplasmic zones occupied by proliferated smooth endoplasmic reticulum (SER) profiles had greatly reduced in size. Many regular stacks of granular endoplasmic reticulum reappeared at the same stage. The mitochondria had enlarged considerably at 48 hr. There were fewer lipid inclusions at 48 hr than at earlier stages. Huge cytolysosomes were observed, and a greater number of multivesicular bodies than previously observed were seen in the hepatocyte cytoplasm. It is concluded that after administration of a single dose of 800 mg/kg b.w. of TAO there was a net recovery of the hepatocyte ultrastructure at the 48 hr stage.

Original languageEnglish
Title of host publicationAnnali Sclavo - Rivista di Microbiologia e di Immunologia
Number of pages20
Publication statusPublished - 1973

ASJC Scopus subject areas

  • Medicine(all)


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