Effects of tumour necrosis factor-α inhibitors in mothers and daughters concordant for HLA-B27- positive ankylosing spondylitis

Francesco Caso, Luisa Costa, Antonio Del Puente, Donato Rigante, Carlo Selmi, Marta Fabbroni, Raffaele Scarpa, Mauro Galeazzi, Bruno Frediani, Luca Cantarini

Research output: Contribution to journalArticle

Abstract

Objective. Pharmacogenomics is considered as the new frontier to predict the response to treatments and it can also be based on the comparison of family members being treated for the same condition. No data are available on the impact of anti-tumour necrosis factor (TNF)-α therapies in members of the same family with ankylosing spondylitis (AS). Methods. We describe three motherdaughter couples concordant for AS and HLA-B27, both treated with TNF-α inhibitors, for whom the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), and Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP were evaluated during a follow-up of 24 months. Results. All patients manifested improvements of all scores, but the daughters had a more prominent effect achieving faster complete disease remission. Conclusion. We hypothesise that longer standing chronic inflammation and older age may cause a less prompt and effective response to treatment in SA when compared with their genetically related controls.

Original languageEnglish
Pages (from-to)411-413
Number of pages3
JournalClinical and Experimental Rheumatology
Volume33
Issue number3
Publication statusPublished - 2015

Keywords

  • Adalimumab
  • Etanercept
  • Familial spondyloarthritis
  • Pharmacogenomics

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Fingerprint Dive into the research topics of 'Effects of tumour necrosis factor-α inhibitors in mothers and daughters concordant for HLA-B27- positive ankylosing spondylitis'. Together they form a unique fingerprint.

  • Cite this

    Caso, F., Costa, L., Puente, A. D., Rigante, D., Selmi, C., Fabbroni, M., Scarpa, R., Galeazzi, M., Frediani, B., & Cantarini, L. (2015). Effects of tumour necrosis factor-α inhibitors in mothers and daughters concordant for HLA-B27- positive ankylosing spondylitis. Clinical and Experimental Rheumatology, 33(3), 411-413.