Effects of unilateral pedunculopontine stimulation on electromyographic activation patterns during gait in individual patients with Parkinson's disease

Pietro Caliandro, A. Insola, E. Scarnati, L. Padua, G. Russo, E. Granieri, P. Mazzone

Research output: Contribution to journalArticle

Abstract

In Parkinson's disease (PD), the effects of deep brain stimulation of the pedunculopontine nucleus (PPTg- DBS) on gait has been object of international debate. Some evidence demonstrated that, in the late swing-early stance phase of gait cycle, a reduced surface electromyographic activation (sEMG) of tibialis anterior (TA) is linked to the striatal dopamine deficiency in PD patients. In the present study we report preliminary results on the effect of PPTg- DBS on electromyographic patterns during gait in individual PD patients. To evaluate the sEMG amplitude of TA, the root mean square (RMS) of the TA burst in late swing-early stance phase (RMS-A) was normalized as a percent of the RMS of the TA burst in late stance-early swing (RMS-B). We studied three male patients in the following conditions: on PPTg-DBS/on L-dopa, on PPTg-DBS/off L-dopa, off PPTg-DBS/on L-dopa, off PPTg-DBS/off L-dopa. For each assessment the UPDRS III was filled in. We observed no difference between on PPTg-DBS/off L-dopa and off PPTg- DBS/off L-dopa in UPDRS III scores. In off PPTg-DBS/off L-dopa, patient A (right implant) showed absence of the right and left RMSA, respectively, in 80% and 83% of gait cycles. PatientB(right implant) showed absence of the rightRMS-A in 86% of cycles. RMS-A of the patient C (left implant) was bilaterally normal. In on PPTg- DBS/off L-dopa, no patient showed reduced RMS-A. Although the very low number of subjects we evaluated, our observations suggest that PPTg plays a role in modulating TA activation pattern during the steady state of gait.

Original languageEnglish
Pages (from-to)1477-1486
Number of pages10
JournalJournal of Neural Transmission
Volume118
Issue number10
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Deep brain stimulation
  • Gait
  • Parkinson's disease
  • Pedunculopontine nucleus

ASJC Scopus subject areas

  • Biological Psychiatry
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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