Effects of unilateral stellate ganglion blockade on the arrhythmias associated with coronary occlusion

Peter J. Schwartz, H. Lowell Stone, Arthur M. Brown

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

In anesthetized dogs the circumflex and/or the anterior descending coronary artery were briefly occluded (10 to 90 seconds) and ectopic beats occurring during the occlusion or for 60 seconds following release were counted. Control occlusions were alternated with occlusions performed during complete, reversible, unilateral blockade of either the right or the left stellate ganglion. This was achieved with thermodes through which coolant was circulated. In this way the shortcomings associated with stellectomy, which is irreversible, are avoided. Blockade of the right stellate ganglion increased the number of ectopic beats associated with coronary occlusion. The occurrence of episodes of ventricular tachycardia and fibrillation was also greater. By contrast, blockade of the left stellate ganglion reduced or abolished occlusion-induced arrhythmias. These effects are independent of changes in heart rate or vagal activity; they depend solely upon unilateral alteration in symathetic tone, and are not demonstrable when such tone is low. We suggest that the right and left cardiac sympathetic nerves have a different influence upon cardiac excitability.

Original languageEnglish
Pages (from-to)589-599
Number of pages11
JournalAmerican Heart Journal
Volume92
Issue number5
DOIs
Publication statusPublished - 1976

Fingerprint

Stellate Ganglion
Coronary Occlusion
Cardiac Arrhythmias
Ventricular Fibrillation
Ventricular Tachycardia
Coronary Vessels
Heart Rate
Dogs

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effects of unilateral stellate ganglion blockade on the arrhythmias associated with coronary occlusion. / Schwartz, Peter J.; Stone, H. Lowell; Brown, Arthur M.

In: American Heart Journal, Vol. 92, No. 5, 1976, p. 589-599.

Research output: Contribution to journalArticle

@article{b6d162f8efb44cd781b4d4576492be4f,
title = "Effects of unilateral stellate ganglion blockade on the arrhythmias associated with coronary occlusion",
abstract = "In anesthetized dogs the circumflex and/or the anterior descending coronary artery were briefly occluded (10 to 90 seconds) and ectopic beats occurring during the occlusion or for 60 seconds following release were counted. Control occlusions were alternated with occlusions performed during complete, reversible, unilateral blockade of either the right or the left stellate ganglion. This was achieved with thermodes through which coolant was circulated. In this way the shortcomings associated with stellectomy, which is irreversible, are avoided. Blockade of the right stellate ganglion increased the number of ectopic beats associated with coronary occlusion. The occurrence of episodes of ventricular tachycardia and fibrillation was also greater. By contrast, blockade of the left stellate ganglion reduced or abolished occlusion-induced arrhythmias. These effects are independent of changes in heart rate or vagal activity; they depend solely upon unilateral alteration in symathetic tone, and are not demonstrable when such tone is low. We suggest that the right and left cardiac sympathetic nerves have a different influence upon cardiac excitability.",
author = "Schwartz, {Peter J.} and Stone, {H. Lowell} and Brown, {Arthur M.}",
year = "1976",
doi = "10.1016/S0002-8703(76)80078-6",
language = "English",
volume = "92",
pages = "589--599",
journal = "American Heart Journal",
issn = "0002-8703",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Effects of unilateral stellate ganglion blockade on the arrhythmias associated with coronary occlusion

AU - Schwartz, Peter J.

AU - Stone, H. Lowell

AU - Brown, Arthur M.

PY - 1976

Y1 - 1976

N2 - In anesthetized dogs the circumflex and/or the anterior descending coronary artery were briefly occluded (10 to 90 seconds) and ectopic beats occurring during the occlusion or for 60 seconds following release were counted. Control occlusions were alternated with occlusions performed during complete, reversible, unilateral blockade of either the right or the left stellate ganglion. This was achieved with thermodes through which coolant was circulated. In this way the shortcomings associated with stellectomy, which is irreversible, are avoided. Blockade of the right stellate ganglion increased the number of ectopic beats associated with coronary occlusion. The occurrence of episodes of ventricular tachycardia and fibrillation was also greater. By contrast, blockade of the left stellate ganglion reduced or abolished occlusion-induced arrhythmias. These effects are independent of changes in heart rate or vagal activity; they depend solely upon unilateral alteration in symathetic tone, and are not demonstrable when such tone is low. We suggest that the right and left cardiac sympathetic nerves have a different influence upon cardiac excitability.

AB - In anesthetized dogs the circumflex and/or the anterior descending coronary artery were briefly occluded (10 to 90 seconds) and ectopic beats occurring during the occlusion or for 60 seconds following release were counted. Control occlusions were alternated with occlusions performed during complete, reversible, unilateral blockade of either the right or the left stellate ganglion. This was achieved with thermodes through which coolant was circulated. In this way the shortcomings associated with stellectomy, which is irreversible, are avoided. Blockade of the right stellate ganglion increased the number of ectopic beats associated with coronary occlusion. The occurrence of episodes of ventricular tachycardia and fibrillation was also greater. By contrast, blockade of the left stellate ganglion reduced or abolished occlusion-induced arrhythmias. These effects are independent of changes in heart rate or vagal activity; they depend solely upon unilateral alteration in symathetic tone, and are not demonstrable when such tone is low. We suggest that the right and left cardiac sympathetic nerves have a different influence upon cardiac excitability.

UR - http://www.scopus.com/inward/record.url?scp=0017085824&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017085824&partnerID=8YFLogxK

U2 - 10.1016/S0002-8703(76)80078-6

DO - 10.1016/S0002-8703(76)80078-6

M3 - Article

VL - 92

SP - 589

EP - 599

JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

IS - 5

ER -