Effects of uremia, acetate and bicarbonate dialysis on beta-adrenergic responsiveness as assessed by epinephrine-stimulated adenylate cyclase

Giorgio Fuiano, Antonio Dal Canton, Mario Maj, Angelo Testa, Bruno Memoli, Giuseppe Conte, Maria Grazia Ariano, Luigi Guarriello, Domenico Russo, Vittorio E. Andreucci

Research output: Contribution to journalArticlepeer-review

Abstract

This study was designed to evaluate β-adrenergic responsiveness as assessed by the generation of cyclic AMP after the subcutaneous administration of epinephrine in 31 subjects: Normal controls, patients with chronic renal insufficiency, hemodynamically stable patients on chronic acetate dialysis and hemodynamically unstable patients with acetate intolerance on chronic bicarbonate dialysis. As compared with controls, only unstable patients on bicarbonate dialysis presented impaired β-responsiveness, which, in turn, was acutely reduced only after acetate but not bicarbonate dialysis. Our results show that acetate dialysis impairs the β-adrenergic responsiveness and that the observed β-hyporesponsiveness in unstable patients with acetate intolerance may represent part of a broader spectrum of autonomic dysfunction which may develop in some patients on chronic hemodialysis.

Original languageEnglish
Pages (from-to)303-308
Number of pages6
JournalAmerican Journal of Nephrology
Volume9
Issue number4
DOIs
Publication statusPublished - 1989

Keywords

  • Cyclic AMP
  • Dialysis
  • Uremia
  • β-Receptors

ASJC Scopus subject areas

  • Nephrology

Fingerprint Dive into the research topics of 'Effects of uremia, acetate and bicarbonate dialysis on beta-adrenergic responsiveness as assessed by epinephrine-stimulated adenylate cyclase'. Together they form a unique fingerprint.

Cite this