Patiens affected by Partial Epilepsy are usually treated with CBZ as a first choice drug, even if recent reports stress a comparable efficacy of VPA; recently, LTG has been showed to be effective in nearly 30% of drug- resistant Partial Epilepsies. A better effect of LTG has been observed in drug-resistant Generalized Epilepsies, but the possibility that this result is due to the VPA+LTG association has been raised. The aim of this study was to test the efficacy of the association of VPA + LTG in Partial Epilepsy pts resistant to CBZ+LTG. Twenty five pts affected by Partial Epilepsy entered the study. Twenty-two were treated with CBZ+LTG, while 3 were on CBZ monotherapy since the association of CBZ+LTG had given severe side effects. In all subjects VPA was added with a slow titration period. In 3 pts treated with CBZ alone, add-on of VPA did not lead to favorable results, and consequently LTG was successively added to the drug regimen. Consequently, all 25 pts were treated with CBZ+VPA+LTG. In 11 pts (44%) a reduction of seizures greater than 50% was observed; CBZ was slowly tapered without seizure increase. These preliminary results seem to suggest that the association of VPA+LTG could be a choice in drug-resistant Partial Epilepsy patiens.
|Translated title of the contribution||Effects of Valproate or of Valproate-Lamotrigine association in partial epilepsy patients resistent to Carbamazepine or to Carbamazepine-Lamotrigine association: Preliminary results|
|Number of pages||3|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Clinical Neurology