Effetti del VPA o dell'associazione VPA+LTG in pazienti con epilessia parziale farmacoresistenti alla CBZ e alla associazione CBZ+LTG: Dati preliminari

Translated title of the contribution: Effects of Valproate or of Valproate-Lamotrigine association in partial epilepsy patients resistent to Carbamazepine or to Carbamazepine-Lamotrigine association: Preliminary results

S. Striano, L. Bilo, R. Meo, P. Ruosi, C. Nocerino, V. Loreto, A. Mariniello

Research output: Contribution to journalArticlepeer-review

Abstract

Patiens affected by Partial Epilepsy are usually treated with CBZ as a first choice drug, even if recent reports stress a comparable efficacy of VPA; recently, LTG has been showed to be effective in nearly 30% of drug- resistant Partial Epilepsies. A better effect of LTG has been observed in drug-resistant Generalized Epilepsies, but the possibility that this result is due to the VPA+LTG association has been raised. The aim of this study was to test the efficacy of the association of VPA + LTG in Partial Epilepsy pts resistant to CBZ+LTG. Twenty five pts affected by Partial Epilepsy entered the study. Twenty-two were treated with CBZ+LTG, while 3 were on CBZ monotherapy since the association of CBZ+LTG had given severe side effects. In all subjects VPA was added with a slow titration period. In 3 pts treated with CBZ alone, add-on of VPA did not lead to favorable results, and consequently LTG was successively added to the drug regimen. Consequently, all 25 pts were treated with CBZ+VPA+LTG. In 11 pts (44%) a reduction of seizures greater than 50% was observed; CBZ was slowly tapered without seizure increase. These preliminary results seem to suggest that the association of VPA+LTG could be a choice in drug-resistant Partial Epilepsy patiens.

Translated title of the contributionEffects of Valproate or of Valproate-Lamotrigine association in partial epilepsy patients resistent to Carbamazepine or to Carbamazepine-Lamotrigine association: Preliminary results
Original languageItalian
Pages (from-to)169-171
Number of pages3
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number99
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Clinical Neurology

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