The possible role of Vasoactive Intestinal Peptide (VLP) and Peptide Histidine Methionine (PHM) as neuromodulators of anterior pituitary function in humans has been suggested. In this work the effects of VIP and PHM on basal and CRH-stimulated ACTH/F secretion were studied in 7 patients with Cushing's disease. An ACTH/F response was found in 3 cases during PHM infusion and in 2 of 6 patients during VIP infusion. When compared to CRH alone, a blunted ACTH response to CRH during PHM occurred in 5 tested patients and during VIP in 3 cases. In conclusion, VIP and PHM are able to rise ACTH/F secretion in some patients with Cushing's disease, but are unable to potentiate the response to CRH, which rather may be reduced.
|Number of pages||6|
|Publication status||Published - 1995|
ASJC Scopus subject areas