Abstract
The possible role of Vasoactive Intestinal Peptide (VLP) and Peptide Histidine Methionine (PHM) as neuromodulators of anterior pituitary function in humans has been suggested. In this work the effects of VIP and PHM on basal and CRH-stimulated ACTH/F secretion were studied in 7 patients with Cushing's disease. An ACTH/F response was found in 3 cases during PHM infusion and in 2 of 6 patients during VIP infusion. When compared to CRH alone, a blunted ACTH response to CRH during PHM occurred in 5 tested patients and during VIP in 3 cases. In conclusion, VIP and PHM are able to rise ACTH/F secretion in some patients with Cushing's disease, but are unable to potentiate the response to CRH, which rather may be reduced.
| Original language | English |
|---|---|
| Pages (from-to) | 313-318 |
| Number of pages | 6 |
| Journal | Neuroendocrinology Letters |
| Volume | 17 |
| Issue number | 4 |
| Publication status | Published - 1995 |
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ASJC Scopus subject areas
- Endocrinology
- Neuroscience(all)
Cite this
Effects of vasoactive intestinal peptide (VIP) and peptide histidine methionine (PHM) on basal and gorticotropin-releasing hormone (CRH)-stimulated ACTH/cortisol secretion in Cushing's disease. / Ambrosi, B.; Colombo, P.; Re, T.; Passini, E.; Bochicchio, D.
In: Neuroendocrinology Letters, Vol. 17, No. 4, 1995, p. 313-318.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of vasoactive intestinal peptide (VIP) and peptide histidine methionine (PHM) on basal and gorticotropin-releasing hormone (CRH)-stimulated ACTH/cortisol secretion in Cushing's disease
AU - Ambrosi, B.
AU - Colombo, P.
AU - Re, T.
AU - Passini, E.
AU - Bochicchio, D.
PY - 1995
Y1 - 1995
N2 - The possible role of Vasoactive Intestinal Peptide (VLP) and Peptide Histidine Methionine (PHM) as neuromodulators of anterior pituitary function in humans has been suggested. In this work the effects of VIP and PHM on basal and CRH-stimulated ACTH/F secretion were studied in 7 patients with Cushing's disease. An ACTH/F response was found in 3 cases during PHM infusion and in 2 of 6 patients during VIP infusion. When compared to CRH alone, a blunted ACTH response to CRH during PHM occurred in 5 tested patients and during VIP in 3 cases. In conclusion, VIP and PHM are able to rise ACTH/F secretion in some patients with Cushing's disease, but are unable to potentiate the response to CRH, which rather may be reduced.
AB - The possible role of Vasoactive Intestinal Peptide (VLP) and Peptide Histidine Methionine (PHM) as neuromodulators of anterior pituitary function in humans has been suggested. In this work the effects of VIP and PHM on basal and CRH-stimulated ACTH/F secretion were studied in 7 patients with Cushing's disease. An ACTH/F response was found in 3 cases during PHM infusion and in 2 of 6 patients during VIP infusion. When compared to CRH alone, a blunted ACTH response to CRH during PHM occurred in 5 tested patients and during VIP in 3 cases. In conclusion, VIP and PHM are able to rise ACTH/F secretion in some patients with Cushing's disease, but are unable to potentiate the response to CRH, which rather may be reduced.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029565158&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0029565158
VL - 17
SP - 313
EP - 318
JO - Neuroendocrinology Letters
JF - Neuroendocrinology Letters
SN - 0172-780X
IS - 4
ER -