Effects of ventilation modalities on near-infrared spectroscopy in surgically corrected CDH infants

Andrea Conforti, Paola Giliberti, Francesca Landolfo, Laura Valfrè, Claudia Columbo, Vito Mondi, Irma Capolupo, Andrea Dotta, Pietro Bagolan

Research output: Contribution to journalArticle

Abstract

Background Near-infrared spectroscopy (NIRS) is a noninvasive technique for monitoring tissue oxygenation and perfusion. The aim of this study was to evaluate cerebral and splanchnic NIRS changes in CDH operated infants enrolled into the VICI trial and therefore randomized for ventilatory modalities. Materials and methods CDH newborns enrolled into the VICI trial (Netherlands Trial Register, NTR 1310) were randomized at birth for high-frequency oscillatory ventilation (HFOV) or conventional mechanical ventilation (CMV) according to the trial. Cerebral oxygenation (rSO2C) and splanchnic oxygenation (rSO2S) were obtained by NIRS (INVOS 5100; Somanetics, Troy, MI) before and after surgery. Variations in rSO2C and rSO2S were evaluated. Mann-Whitney test and one-way ANOVA were used as appropriate. p <0.05 was considered significant. Results Thirteen VICI trial patients underwent surgical repair between March 2011 and December 2012, and were enrolled in the study. Seven patients were assigned to HFOV and six to CMV group respectively. During surgery, a significant reduction in rSO2C (p = 0.0001) and rSO2S (p = 0.005) were observed. HFOV patients experienced prolonged reduction in rSO2C value (p = 0.003) while rSO2S did not vary between HFOV and CMV (p = 0.94). Conclusions Surgical CDH repair was associated with decrease of cerebral and splanchnic oxygenation, regardless of ventilation. Patients ventilated by HFOV need a longer time interval to recovery normal rSO2C values, than those ventilated by CMV. This may be owing to a different impact of HFOV on patients' hemodynamic status with a higher impairment on total venous return and its negative consequences on cardiac output.

Original languageEnglish
Pages (from-to)349-353
Number of pages5
JournalJournal of Pediatric Surgery
Volume51
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

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High-Frequency Ventilation
Near-Infrared Spectroscopy
Viscera
Ventilation
Artificial Respiration
Cardiac Output
Netherlands
Analysis of Variance
Reference Values
Perfusion
Hemodynamics
Parturition
Newborn Infant

Keywords

  • CMV
  • Congenital diaphragmatic hernia
  • conventional mechanical ventilation
  • HFOV
  • high-frequency oscillatory ventilation
  • NIRS

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Effects of ventilation modalities on near-infrared spectroscopy in surgically corrected CDH infants. / Conforti, Andrea; Giliberti, Paola; Landolfo, Francesca; Valfrè, Laura; Columbo, Claudia; Mondi, Vito; Capolupo, Irma; Dotta, Andrea; Bagolan, Pietro.

In: Journal of Pediatric Surgery, Vol. 51, No. 3, 01.03.2016, p. 349-353.

Research output: Contribution to journalArticle

Conforti, Andrea ; Giliberti, Paola ; Landolfo, Francesca ; Valfrè, Laura ; Columbo, Claudia ; Mondi, Vito ; Capolupo, Irma ; Dotta, Andrea ; Bagolan, Pietro. / Effects of ventilation modalities on near-infrared spectroscopy in surgically corrected CDH infants. In: Journal of Pediatric Surgery. 2016 ; Vol. 51, No. 3. pp. 349-353.
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abstract = "Background Near-infrared spectroscopy (NIRS) is a noninvasive technique for monitoring tissue oxygenation and perfusion. The aim of this study was to evaluate cerebral and splanchnic NIRS changes in CDH operated infants enrolled into the VICI trial and therefore randomized for ventilatory modalities. Materials and methods CDH newborns enrolled into the VICI trial (Netherlands Trial Register, NTR 1310) were randomized at birth for high-frequency oscillatory ventilation (HFOV) or conventional mechanical ventilation (CMV) according to the trial. Cerebral oxygenation (rSO2C) and splanchnic oxygenation (rSO2S) were obtained by NIRS (INVOS 5100; Somanetics, Troy, MI) before and after surgery. Variations in rSO2C and rSO2S were evaluated. Mann-Whitney test and one-way ANOVA were used as appropriate. p <0.05 was considered significant. Results Thirteen VICI trial patients underwent surgical repair between March 2011 and December 2012, and were enrolled in the study. Seven patients were assigned to HFOV and six to CMV group respectively. During surgery, a significant reduction in rSO2C (p = 0.0001) and rSO2S (p = 0.005) were observed. HFOV patients experienced prolonged reduction in rSO2C value (p = 0.003) while rSO2S did not vary between HFOV and CMV (p = 0.94). Conclusions Surgical CDH repair was associated with decrease of cerebral and splanchnic oxygenation, regardless of ventilation. Patients ventilated by HFOV need a longer time interval to recovery normal rSO2C values, than those ventilated by CMV. This may be owing to a different impact of HFOV on patients' hemodynamic status with a higher impairment on total venous return and its negative consequences on cardiac output.",
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T1 - Effects of ventilation modalities on near-infrared spectroscopy in surgically corrected CDH infants

AU - Conforti, Andrea

AU - Giliberti, Paola

AU - Landolfo, Francesca

AU - Valfrè, Laura

AU - Columbo, Claudia

AU - Mondi, Vito

AU - Capolupo, Irma

AU - Dotta, Andrea

AU - Bagolan, Pietro

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Background Near-infrared spectroscopy (NIRS) is a noninvasive technique for monitoring tissue oxygenation and perfusion. The aim of this study was to evaluate cerebral and splanchnic NIRS changes in CDH operated infants enrolled into the VICI trial and therefore randomized for ventilatory modalities. Materials and methods CDH newborns enrolled into the VICI trial (Netherlands Trial Register, NTR 1310) were randomized at birth for high-frequency oscillatory ventilation (HFOV) or conventional mechanical ventilation (CMV) according to the trial. Cerebral oxygenation (rSO2C) and splanchnic oxygenation (rSO2S) were obtained by NIRS (INVOS 5100; Somanetics, Troy, MI) before and after surgery. Variations in rSO2C and rSO2S were evaluated. Mann-Whitney test and one-way ANOVA were used as appropriate. p <0.05 was considered significant. Results Thirteen VICI trial patients underwent surgical repair between March 2011 and December 2012, and were enrolled in the study. Seven patients were assigned to HFOV and six to CMV group respectively. During surgery, a significant reduction in rSO2C (p = 0.0001) and rSO2S (p = 0.005) were observed. HFOV patients experienced prolonged reduction in rSO2C value (p = 0.003) while rSO2S did not vary between HFOV and CMV (p = 0.94). Conclusions Surgical CDH repair was associated with decrease of cerebral and splanchnic oxygenation, regardless of ventilation. Patients ventilated by HFOV need a longer time interval to recovery normal rSO2C values, than those ventilated by CMV. This may be owing to a different impact of HFOV on patients' hemodynamic status with a higher impairment on total venous return and its negative consequences on cardiac output.

AB - Background Near-infrared spectroscopy (NIRS) is a noninvasive technique for monitoring tissue oxygenation and perfusion. The aim of this study was to evaluate cerebral and splanchnic NIRS changes in CDH operated infants enrolled into the VICI trial and therefore randomized for ventilatory modalities. Materials and methods CDH newborns enrolled into the VICI trial (Netherlands Trial Register, NTR 1310) were randomized at birth for high-frequency oscillatory ventilation (HFOV) or conventional mechanical ventilation (CMV) according to the trial. Cerebral oxygenation (rSO2C) and splanchnic oxygenation (rSO2S) were obtained by NIRS (INVOS 5100; Somanetics, Troy, MI) before and after surgery. Variations in rSO2C and rSO2S were evaluated. Mann-Whitney test and one-way ANOVA were used as appropriate. p <0.05 was considered significant. Results Thirteen VICI trial patients underwent surgical repair between March 2011 and December 2012, and were enrolled in the study. Seven patients were assigned to HFOV and six to CMV group respectively. During surgery, a significant reduction in rSO2C (p = 0.0001) and rSO2S (p = 0.005) were observed. HFOV patients experienced prolonged reduction in rSO2C value (p = 0.003) while rSO2S did not vary between HFOV and CMV (p = 0.94). Conclusions Surgical CDH repair was associated with decrease of cerebral and splanchnic oxygenation, regardless of ventilation. Patients ventilated by HFOV need a longer time interval to recovery normal rSO2C values, than those ventilated by CMV. This may be owing to a different impact of HFOV on patients' hemodynamic status with a higher impairment on total venous return and its negative consequences on cardiac output.

KW - CMV

KW - Congenital diaphragmatic hernia

KW - conventional mechanical ventilation

KW - HFOV

KW - high-frequency oscillatory ventilation

KW - NIRS

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