Effects of verapamil SR and atenolol on 24-hour blood pressure and heart rate in hypertension patients with coronary artery disease: An international verapamil SR-trandolapril ambulatory monitoring substudy

Scott J. Denardo, Yan Gong, Rhonda M. Cooper-Dehoff, Csaba Farsang, Matyas Keltai, László Szirmai, Franz H. Messerli, Anthony A. Bavry, Eileen M. Handberg, Giuseppe Mancia, Carl J. Pepine

Research output: Contribution to journalArticle

Abstract

Elevated nighttime blood pressure (BP) and heart rate (HR), increased BP and HR variability, and altered diurnal variations of BP and HR (nighttime dipping and morning surge) in patients with systemic hypertension are each associated with increased adverse cardiovascular events. However, there are no reports on the effect of hypertension treatment on these important hemodynamic parameters in the growing population of hypertensive patients with atherosclerotic coronary artery disease (CAD). This was a pre-specified subgroup analysis of the INternational VErapamil SR-Trandolapril STudy (INVEST), which involved 22,576 clinically stable patients aged >50 years with hypertension and CAD randomized to either verapamil SR-oratenolol-based hypertension treatment strategies. The subgroup consisted of 117 patients undergoing 24-hour ambulatory monitoring at baseline and after 1 year of treatment. Hourly systolic and diastolic BP (SBP and DBP) decreased after 1 year for both verapamil SR- and atenolol-based treatment strategies compared with baseline (P

Original languageEnglish
Article numbere0122726
JournalPLoS One
Volume10
Issue number4
DOIs
Publication statusPublished - Apr 2 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Denardo, S. J., Gong, Y., Cooper-Dehoff, R. M., Farsang, C., Keltai, M., Szirmai, L., Messerli, F. H., Bavry, A. A., Handberg, E. M., Mancia, G., & Pepine, C. J. (2015). Effects of verapamil SR and atenolol on 24-hour blood pressure and heart rate in hypertension patients with coronary artery disease: An international verapamil SR-trandolapril ambulatory monitoring substudy. PLoS One, 10(4), [e0122726]. https://doi.org/10.1371/journal.pone.0122726