Effects of verapamil SR and atenolol on 24-hour blood pressure and heart rate in hypertension patients with coronary artery disease: An international verapamil SR-trandolapril ambulatory monitoring substudy

Scott J. Denardo, Yan Gong, Rhonda M. Cooper-Dehoff, Csaba Farsang, Matyas Keltai, László Szirmai, Franz H. Messerli, Anthony A. Bavry, Eileen M. Handberg, Giuseppe Mancia, Carl J. Pepine

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Elevated nighttime blood pressure (BP) and heart rate (HR), increased BP and HR variability, and altered diurnal variations of BP and HR (nighttime dipping and morning surge) in patients with systemic hypertension are each associated with increased adverse cardiovascular events. However, there are no reports on the effect of hypertension treatment on these important hemodynamic parameters in the growing population of hypertensive patients with atherosclerotic coronary artery disease (CAD). This was a pre-specified subgroup analysis of the INternational VErapamil SR-Trandolapril STudy (INVEST), which involved 22,576 clinically stable patients aged >50 years with hypertension and CAD randomized to either verapamil SR-oratenolol-based hypertension treatment strategies. The subgroup consisted of 117 patients undergoing 24-hour ambulatory monitoring at baseline and after 1 year of treatment. Hourly systolic and diastolic BP (SBP and DBP) decreased after 1 year for both verapamil SR- and atenolol-based treatment strategies compared with baseline (P

Original languageEnglish
Article numbere0122726
JournalPLoS One
Volume10
Issue number4
DOIs
Publication statusPublished - Apr 2 2015

Fingerprint

trandolapril
Ambulatory Monitoring
verapamil
Atenolol
Blood pressure
Verapamil
hypertension
blood pressure
heart rate
Coronary Artery Disease
Heart Rate
Blood Pressure
Hypertension
Monitoring
monitoring
diastolic blood pressure
Hemodynamics
systolic blood pressure
dipping
hemodynamics

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Effects of verapamil SR and atenolol on 24-hour blood pressure and heart rate in hypertension patients with coronary artery disease : An international verapamil SR-trandolapril ambulatory monitoring substudy. / Denardo, Scott J.; Gong, Yan; Cooper-Dehoff, Rhonda M.; Farsang, Csaba; Keltai, Matyas; Szirmai, László; Messerli, Franz H.; Bavry, Anthony A.; Handberg, Eileen M.; Mancia, Giuseppe; Pepine, Carl J.

In: PLoS One, Vol. 10, No. 4, e0122726, 02.04.2015.

Research output: Contribution to journalArticle

Denardo, SJ, Gong, Y, Cooper-Dehoff, RM, Farsang, C, Keltai, M, Szirmai, L, Messerli, FH, Bavry, AA, Handberg, EM, Mancia, G & Pepine, CJ 2015, 'Effects of verapamil SR and atenolol on 24-hour blood pressure and heart rate in hypertension patients with coronary artery disease: An international verapamil SR-trandolapril ambulatory monitoring substudy', PLoS One, vol. 10, no. 4, e0122726. https://doi.org/10.1371/journal.pone.0122726
Denardo, Scott J. ; Gong, Yan ; Cooper-Dehoff, Rhonda M. ; Farsang, Csaba ; Keltai, Matyas ; Szirmai, László ; Messerli, Franz H. ; Bavry, Anthony A. ; Handberg, Eileen M. ; Mancia, Giuseppe ; Pepine, Carl J. / Effects of verapamil SR and atenolol on 24-hour blood pressure and heart rate in hypertension patients with coronary artery disease : An international verapamil SR-trandolapril ambulatory monitoring substudy. In: PLoS One. 2015 ; Vol. 10, No. 4.
@article{57fe151cb67444caa1d3490d13fc8eff,
title = "Effects of verapamil SR and atenolol on 24-hour blood pressure and heart rate in hypertension patients with coronary artery disease: An international verapamil SR-trandolapril ambulatory monitoring substudy",
abstract = "Elevated nighttime blood pressure (BP) and heart rate (HR), increased BP and HR variability, and altered diurnal variations of BP and HR (nighttime dipping and morning surge) in patients with systemic hypertension are each associated with increased adverse cardiovascular events. However, there are no reports on the effect of hypertension treatment on these important hemodynamic parameters in the growing population of hypertensive patients with atherosclerotic coronary artery disease (CAD). This was a pre-specified subgroup analysis of the INternational VErapamil SR-Trandolapril STudy (INVEST), which involved 22,576 clinically stable patients aged >50 years with hypertension and CAD randomized to either verapamil SR-oratenolol-based hypertension treatment strategies. The subgroup consisted of 117 patients undergoing 24-hour ambulatory monitoring at baseline and after 1 year of treatment. Hourly systolic and diastolic BP (SBP and DBP) decreased after 1 year for both verapamil SR- and atenolol-based treatment strategies compared with baseline (P",
author = "Denardo, {Scott J.} and Yan Gong and Cooper-Dehoff, {Rhonda M.} and Csaba Farsang and Matyas Keltai and L{\'a}szl{\'o} Szirmai and Messerli, {Franz H.} and Bavry, {Anthony A.} and Handberg, {Eileen M.} and Giuseppe Mancia and Pepine, {Carl J.}",
year = "2015",
month = "4",
day = "2",
doi = "10.1371/journal.pone.0122726",
language = "English",
volume = "10",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

TY - JOUR

T1 - Effects of verapamil SR and atenolol on 24-hour blood pressure and heart rate in hypertension patients with coronary artery disease

T2 - An international verapamil SR-trandolapril ambulatory monitoring substudy

AU - Denardo, Scott J.

AU - Gong, Yan

AU - Cooper-Dehoff, Rhonda M.

AU - Farsang, Csaba

AU - Keltai, Matyas

AU - Szirmai, László

AU - Messerli, Franz H.

AU - Bavry, Anthony A.

AU - Handberg, Eileen M.

AU - Mancia, Giuseppe

AU - Pepine, Carl J.

PY - 2015/4/2

Y1 - 2015/4/2

N2 - Elevated nighttime blood pressure (BP) and heart rate (HR), increased BP and HR variability, and altered diurnal variations of BP and HR (nighttime dipping and morning surge) in patients with systemic hypertension are each associated with increased adverse cardiovascular events. However, there are no reports on the effect of hypertension treatment on these important hemodynamic parameters in the growing population of hypertensive patients with atherosclerotic coronary artery disease (CAD). This was a pre-specified subgroup analysis of the INternational VErapamil SR-Trandolapril STudy (INVEST), which involved 22,576 clinically stable patients aged >50 years with hypertension and CAD randomized to either verapamil SR-oratenolol-based hypertension treatment strategies. The subgroup consisted of 117 patients undergoing 24-hour ambulatory monitoring at baseline and after 1 year of treatment. Hourly systolic and diastolic BP (SBP and DBP) decreased after 1 year for both verapamil SR- and atenolol-based treatment strategies compared with baseline (P

AB - Elevated nighttime blood pressure (BP) and heart rate (HR), increased BP and HR variability, and altered diurnal variations of BP and HR (nighttime dipping and morning surge) in patients with systemic hypertension are each associated with increased adverse cardiovascular events. However, there are no reports on the effect of hypertension treatment on these important hemodynamic parameters in the growing population of hypertensive patients with atherosclerotic coronary artery disease (CAD). This was a pre-specified subgroup analysis of the INternational VErapamil SR-Trandolapril STudy (INVEST), which involved 22,576 clinically stable patients aged >50 years with hypertension and CAD randomized to either verapamil SR-oratenolol-based hypertension treatment strategies. The subgroup consisted of 117 patients undergoing 24-hour ambulatory monitoring at baseline and after 1 year of treatment. Hourly systolic and diastolic BP (SBP and DBP) decreased after 1 year for both verapamil SR- and atenolol-based treatment strategies compared with baseline (P

UR - http://www.scopus.com/inward/record.url?scp=84926616156&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926616156&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0122726

DO - 10.1371/journal.pone.0122726

M3 - Article

AN - SCOPUS:84926616156

VL - 10

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 4

M1 - e0122726

ER -