Effects of verbascoside biotechnologically produced by Syringa vulgaris plant cell cultures in a rodent model of colitis

Emanuela Mazzon, Emanuela Esposito, Rosanna Di Paola, Luisa Riccardi, Rocco Caminiti, Roberto Dal Toso, Giovanna Pressi, Salvatore Cuzzocrea

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of the present study was to examine the effects of verbascoside (VB) in rats subjected to experimental colitis. Colitis was induced in rats by intracolonic instillation of 2,4 dinitrobenzene sulfonic acid (DNBS; 25 mg/rat). VB was administered daily per os (0.2 and 2 mg/kg) 4 days after DNBS administration in the colon. Treatment with VB significantly (P∈

Original languageEnglish
Pages (from-to)79-94
Number of pages16
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume380
Issue number1
DOIs
Publication statusPublished - Jul 2009

Keywords

  • Colon damage
  • DNBS
  • Free radicals
  • Inflammation
  • Metalloproteinase

ASJC Scopus subject areas

  • Pharmacology

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