Effects of vitamin C on fibroblasts from sporadic Alzheimer's disease patients

Egidia Costanzi, Sabata Martino, Emanuele Persichetti, Roberto Tiribuzi, Carlo Massini, Giorgio Bernardi, Antonio Orlacchio, Aldo Orlacchio

Research output: Contribution to journalArticle

Abstract

Several therapies for Alzheimer's Disease (AD) are currently under investigation. Some studies have reported that concentration of vitamins in biological fluids are lower in AD patients compared to control subjects and clinical evidence has shown the therapeutic potential of vitamin C and E in delaying AD progression. However, the molecular mechanism(s) that are engaged upon their administration in the APP metabolism in vitro or in vivo still need clarifying. Here, we investigate the effects of vitamin C supplementation, at physiological concentration, in skin fibroblasts obtained from SAD and FAD patients. This study shows that SAD patients' fibroblasts exhibited the exclusive appearance of C-terminal fragments, derived from APP processing, without giving rise to the β-amyloid peptide, other than corresponding decreased levels of lysosomal enzymes, such as β-hexosaminidase, α-mannosidase and cathepsins B, L, and D.

Original languageEnglish
Pages (from-to)2510-2515
Number of pages6
JournalNeurochemical Research
Volume33
Issue number12
DOIs
Publication statusPublished - Dec 2008

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Keywords

  • β-Amyloidogenesis
  • Alzheimer's disease
  • Experimental model for AD
  • Lysosomal enzymes
  • Skin fibroblasts
  • Vitamin C

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Biochemistry

Cite this

Costanzi, E., Martino, S., Persichetti, E., Tiribuzi, R., Massini, C., Bernardi, G., Orlacchio, A., & Orlacchio, A. (2008). Effects of vitamin C on fibroblasts from sporadic Alzheimer's disease patients. Neurochemical Research, 33(12), 2510-2515. https://doi.org/10.1007/s11064-007-9539-y