Abstract
The biological significance of vitamin D receptors expressed by glioblastoma and other glial tumours is still unclear. In an effort to clarify this issue we studied the effects of increasing concentrations of 25-dihydroxyvitamin D3 and its metabolite 1 α, 25-dihydroxyvitamin D3 on two human glioblastoma cell lines. Both substances were capable of inducing a significant (> 50%) reduction in growth of the two glioblastoma cell lines at dosages over 5 μM. When the HU 70 cell line was treated by increasing dilutions of 25-dihydroxyvitamin D3 combined with 1 μM all trans-retinoic acid, significant inhibition was apparent even after addition of 25-dihydroxyvitamin D3 in the nanomolar range. Reduction of growth index was mainly due to induced cell death. Our results provide in vitro evidence that vitamin D metabolites alone or in combination with retinoids may be potentially useful agents in the differentiation therapy of human malignant gliomas.
Original language | English |
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Pages (from-to) | 184-190 |
Number of pages | 7 |
Journal | Acta Neurochirurgica |
Volume | 133 |
Issue number | 3-4 |
DOIs | |
Publication status | Published - Sep 1995 |
Keywords
- cell death
- Glioblastoma
- retinoic acid
- vitamin D
ASJC Scopus subject areas
- Surgery
- Clinical Neurology