Effects of vitamin E on liver DNA

Patrizia Russo, Mauro Pala, Silvio Parodi, Carla Ghiara, Nicoletta Ferrari, Giorgio Vidali

Research output: Contribution to journalArticlepeer-review


Vitamin E, both in the form of dl-α-tocopherol and dl-α-tocopheryl acetate, was capable of inducing an increased alkaline elution rate of liver DNA from rats treated i.p. with the vitamin. This activity was clearly both dose- and time-dependent. A statistically significant effect was observed at dosages (1.25-5.00 mg/kg) that are in the range of biological activity of the vitamin in the rat (reabsorption-gestation bioassay). Moreover, the effect was observed at dosages that are clearly not toxic. An increased alkaline elution rate of DNA is usually interpreted as suggestive of DNA damage, however recent observations seem to indicate that functional modifications of chromatin packaging can also affect the elution rate of DNA.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalCancer Letters
Issue number2
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Molecular Biology


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