Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: Results from 2 placebo-controlled studies

Wolfram Doehner, Nina Schoene, Mathias Rauchhaus, Francisco Leyva-Leon, Darrell V. Pavitt, David A. Reaveley, Gerhard Schuler, Andrew J S Coats, Stefan D. Anker, Rainer Hambrecht

Research output: Contribution to journalArticlepeer-review

Abstract

Background - In patients with chronic heart failure (CHF), hyperuricemia is a common finding and is associated with reduced vasodilator capacity and impaired peripheral blood flow. It has been suggested that the causal link of this association is increased xanthine oxidase (XO)-derived oxygen free radical production and endothelial dysfunction. We therefore studied the effects of XO inhibition with allopurinol on endothelial function and peripheral blood flow in CHF patients after intra-arterial infusion and after oral administration in 2 independent placebo-controlled studies. Methods and Results - In 10 CHF patients with normal serum uric acid (UA) levels (315±42 μmol/L) and 9 patients with elevated UA (535±54 μmol/L), endothelium-dependent (acetylcholine infusion) and endothelium-independent (nitroglycerin infusion) vasodilation of the radial artery was determined. Coinfusion of allopurinol (600 μg/min) improved endothelium-dependent but not endothelium-independent vasodilation in hyperuricemic patients (P120 μmol/L in all patients (mean reduction 217±15 μmol/L, P

Original languageEnglish
Pages (from-to)2619-2624
Number of pages6
JournalCirculation
Volume105
Issue number22
DOIs
Publication statusPublished - Jun 5 2002

Keywords

  • Blood flow
  • Endothelium
  • Heart failure

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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