Effects of zinc-fortified drinking skim milk (as functional food) on cytokine release and thymic hormone activity in very old persons: a pilot study

Laura Costarelli, Robertina Giacconi, Marco Malavolta, Andrea Basso, Francesco Piacenza, Mari Luisa DeMartiis, Elvio Giannandrea, Carlo Renieri, Franco Busco, Roberta Galeazzi, Eugenio Mocchegiani

Research output: Contribution to journalArticle

Abstract

Zinc is a relevant nutritional factor for the whole life of an organism because it affects the inflammatory/immune response and antioxidant activity, leading to a healthy state. Despite its important function, the dietary intake of zinc is inadequate in elderly. Possible interventions include food fortification because it does not require changes in dietary patterns, the cost is low and it can reach a large portion of the elderly population, including very old subjects. Studies evaluating the impact of Zn-fortified foods on functional parameters in elderly, in particular, in very old individuals, are missing. The objective of this study was to evaluate the efficacy of consumption of a zinc-fortified drinking skim milk (Zn-FMilk) for a period of 2 months in comparison to standard non-fortified milk (No-FMilk) on some biochemical parameters, zinc status, inflammatory/immune response and on a key parameter of the T cell-mediated immunity (thymulin hormone) in healthy very old subjects. The treatment with zinc-fortified milk (Zn-FMilk) is a good omen to increase the cell-mediated immunity in very old age represented by thymulin activity and some cytokine (IL-12p70, IFN-γ) release. At clinical level, a good healthy state occurs in 70 % of the subjects with no hospitalization after 1 year of the follow-up in comparison to very old control subjects that did not participate to crossover design. In conclusion, the Zn-FMilk can be considered a good functional food for elderly, including older people. It might be a good replacement to the zinc tablets or lozenges taking into account the attitude of old people to uptake milk as a preferential food.

Original languageEnglish
Pages (from-to)9656
Number of pages1
JournalAge
Volume36
Issue number3
DOIs
Publication statusPublished - Jun 1 2014

Fingerprint

Thymus Hormones
Functional Food
Drinking
Zinc
Milk
Cytokines
Circulating Thymic Factor
Cellular Immunity
Fortified Food
Food
Cross-Over Studies
Tablets
Hospitalization
Antioxidants
Hormones
T-Lymphocytes
Costs and Cost Analysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effects of zinc-fortified drinking skim milk (as functional food) on cytokine release and thymic hormone activity in very old persons : a pilot study. / Costarelli, Laura; Giacconi, Robertina; Malavolta, Marco; Basso, Andrea; Piacenza, Francesco; DeMartiis, Mari Luisa; Giannandrea, Elvio; Renieri, Carlo; Busco, Franco; Galeazzi, Roberta; Mocchegiani, Eugenio.

In: Age, Vol. 36, No. 3, 01.06.2014, p. 9656.

Research output: Contribution to journalArticle

@article{d6aa225af82142d1bac515f33ad4f416,
title = "Effects of zinc-fortified drinking skim milk (as functional food) on cytokine release and thymic hormone activity in very old persons: a pilot study",
abstract = "Zinc is a relevant nutritional factor for the whole life of an organism because it affects the inflammatory/immune response and antioxidant activity, leading to a healthy state. Despite its important function, the dietary intake of zinc is inadequate in elderly. Possible interventions include food fortification because it does not require changes in dietary patterns, the cost is low and it can reach a large portion of the elderly population, including very old subjects. Studies evaluating the impact of Zn-fortified foods on functional parameters in elderly, in particular, in very old individuals, are missing. The objective of this study was to evaluate the efficacy of consumption of a zinc-fortified drinking skim milk (Zn-FMilk) for a period of 2 months in comparison to standard non-fortified milk (No-FMilk) on some biochemical parameters, zinc status, inflammatory/immune response and on a key parameter of the T cell-mediated immunity (thymulin hormone) in healthy very old subjects. The treatment with zinc-fortified milk (Zn-FMilk) is a good omen to increase the cell-mediated immunity in very old age represented by thymulin activity and some cytokine (IL-12p70, IFN-γ) release. At clinical level, a good healthy state occurs in 70 {\%} of the subjects with no hospitalization after 1 year of the follow-up in comparison to very old control subjects that did not participate to crossover design. In conclusion, the Zn-FMilk can be considered a good functional food for elderly, including older people. It might be a good replacement to the zinc tablets or lozenges taking into account the attitude of old people to uptake milk as a preferential food.",
author = "Laura Costarelli and Robertina Giacconi and Marco Malavolta and Andrea Basso and Francesco Piacenza and DeMartiis, {Mari Luisa} and Elvio Giannandrea and Carlo Renieri and Franco Busco and Roberta Galeazzi and Eugenio Mocchegiani",
year = "2014",
month = "6",
day = "1",
doi = "10.1007/s11357-014-9656-x",
language = "English",
volume = "36",
pages = "9656",
journal = "Age",
issn = "0161-9152",
publisher = "Springer Netherlands",
number = "3",

}

TY - JOUR

T1 - Effects of zinc-fortified drinking skim milk (as functional food) on cytokine release and thymic hormone activity in very old persons

T2 - a pilot study

AU - Costarelli, Laura

AU - Giacconi, Robertina

AU - Malavolta, Marco

AU - Basso, Andrea

AU - Piacenza, Francesco

AU - DeMartiis, Mari Luisa

AU - Giannandrea, Elvio

AU - Renieri, Carlo

AU - Busco, Franco

AU - Galeazzi, Roberta

AU - Mocchegiani, Eugenio

PY - 2014/6/1

Y1 - 2014/6/1

N2 - Zinc is a relevant nutritional factor for the whole life of an organism because it affects the inflammatory/immune response and antioxidant activity, leading to a healthy state. Despite its important function, the dietary intake of zinc is inadequate in elderly. Possible interventions include food fortification because it does not require changes in dietary patterns, the cost is low and it can reach a large portion of the elderly population, including very old subjects. Studies evaluating the impact of Zn-fortified foods on functional parameters in elderly, in particular, in very old individuals, are missing. The objective of this study was to evaluate the efficacy of consumption of a zinc-fortified drinking skim milk (Zn-FMilk) for a period of 2 months in comparison to standard non-fortified milk (No-FMilk) on some biochemical parameters, zinc status, inflammatory/immune response and on a key parameter of the T cell-mediated immunity (thymulin hormone) in healthy very old subjects. The treatment with zinc-fortified milk (Zn-FMilk) is a good omen to increase the cell-mediated immunity in very old age represented by thymulin activity and some cytokine (IL-12p70, IFN-γ) release. At clinical level, a good healthy state occurs in 70 % of the subjects with no hospitalization after 1 year of the follow-up in comparison to very old control subjects that did not participate to crossover design. In conclusion, the Zn-FMilk can be considered a good functional food for elderly, including older people. It might be a good replacement to the zinc tablets or lozenges taking into account the attitude of old people to uptake milk as a preferential food.

AB - Zinc is a relevant nutritional factor for the whole life of an organism because it affects the inflammatory/immune response and antioxidant activity, leading to a healthy state. Despite its important function, the dietary intake of zinc is inadequate in elderly. Possible interventions include food fortification because it does not require changes in dietary patterns, the cost is low and it can reach a large portion of the elderly population, including very old subjects. Studies evaluating the impact of Zn-fortified foods on functional parameters in elderly, in particular, in very old individuals, are missing. The objective of this study was to evaluate the efficacy of consumption of a zinc-fortified drinking skim milk (Zn-FMilk) for a period of 2 months in comparison to standard non-fortified milk (No-FMilk) on some biochemical parameters, zinc status, inflammatory/immune response and on a key parameter of the T cell-mediated immunity (thymulin hormone) in healthy very old subjects. The treatment with zinc-fortified milk (Zn-FMilk) is a good omen to increase the cell-mediated immunity in very old age represented by thymulin activity and some cytokine (IL-12p70, IFN-γ) release. At clinical level, a good healthy state occurs in 70 % of the subjects with no hospitalization after 1 year of the follow-up in comparison to very old control subjects that did not participate to crossover design. In conclusion, the Zn-FMilk can be considered a good functional food for elderly, including older people. It might be a good replacement to the zinc tablets or lozenges taking into account the attitude of old people to uptake milk as a preferential food.

UR - http://www.scopus.com/inward/record.url?scp=84964314743&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964314743&partnerID=8YFLogxK

U2 - 10.1007/s11357-014-9656-x

DO - 10.1007/s11357-014-9656-x

M3 - Article

C2 - 24771015

VL - 36

SP - 9656

JO - Age

JF - Age

SN - 0161-9152

IS - 3

ER -